{"id":"W3045311409","doi":"10.3390/genes11070825","title":"The Role of BMI1 in Late-Onset Sporadic Alzheimer’s Disease","year":2020,"lang":"en","type":"review","venue":"Genes","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"BMI1; Epigenetics; Mendelian inheritance; Disease; Genetics; Biology; Early-onset Alzheimer's disease; Gene; Dementia; Alzheimer's disease; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003738897,0.0005650874,0.0006887981,0.001262972,0.0001854826,0.0005957837,0.0005876317,0.0006212459,0.002910656],"category_scores_gemma":[0.0004591785,0.0001486551,0.0002368492,0.00112207,0.0002965556,0.0007070003,0.0005438472,0.001073025,0.001786821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003757066,"about_ca_system_score_gemma":0.0006686772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007512176,"about_ca_topic_score_gemma":0.001359234,"domain_scores_codex":[0.9999194,0.00001348544,0.00001314075,0.00001823047,0.00002640018,0.000009373751],"domain_scores_gemma":[0.9998667,0.00005730251,0.00002108187,0.000004149959,0.00003403932,0.00001660584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007433879,0.00002372779,0.0001658085,0.01003517,0.0000535312,0.0001943571,0.00003968719,0.0002497445,0.001695692,0.002985277,0.02228363,0.9621992],"study_design_scores_gemma":[0.00001403416,0.0000861492,0.001125482,0.002751167,0.0001037319,0.001757173,0.00004436302,0.00007422751,0.0005059618,0.002191285,0.9913322,0.00001413313],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001445824,0.9981205,0.0001433542,0.0002872535,0.0002319823,0.000003555733,0.00001988033,0.000006482705,0.001042306],"genre_scores_gemma":[0.0007950329,0.9981192,0.0001289437,0.0001546563,0.000169767,0.000004795249,0.00003536731,0.000001624208,0.0005907476],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002910656,"threshold_uncertainty_score":0.009737074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02798601245484509,"score_gpt":0.3085698923585459,"score_spread":0.2805838799037008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}