{"id":"W3045392621","doi":"10.1002/mc.23238","title":"Low‐dose triptolide enhances antitumor effect of JQ1 on acute myeloid leukemia through inhibiting RNA polymerase II in vitro and in vivo","year":2020,"lang":"en","type":"article","venue":"Molecular Carcinogenesis","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Infectious Diseases Centre","funders":"Natural Science Foundation of Fujian Province; National Natural Science Foundation of China","keywords":"Triptolide; Myeloid leukemia; In vivo; Cancer research; Leukemia; Apoptosis; Biology; Pharmacology; Cell culture; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009408334,0.0002833353,0.0002460965,0.0001920372,0.00008106003,0.0001520032,0.0001426334,0.0001542905,0.0008986417],"category_scores_gemma":[0.00009411278,0.00007682229,0.0001403722,0.000105056,0.0001456105,0.0001354991,0.00009670694,0.0005250456,0.0001945073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001366622,"about_ca_system_score_gemma":0.0001443077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002891915,"about_ca_topic_score_gemma":0.0005226855,"domain_scores_codex":[0.9999225,0.00001449654,0.000008618583,0.00001446844,0.00002078078,0.00001923353],"domain_scores_gemma":[0.9999461,0.00001231026,0.00001293152,0.000004964754,0.000006219238,0.00001751231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002740933,0.00009851543,0.0001616221,0.0000485042,0.000006592422,0.00001877695,0.00001143333,0.0001108151,0.9971057,0.00003580997,0.00005422843,0.002074003],"study_design_scores_gemma":[0.00005511724,0.002199819,0.002750695,0.000005846642,0.00002571149,0.0001191888,0.00001132769,0.0007984129,0.992668,0.00002899899,0.001333595,0.000003365917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99661,0.001482375,0.0009684031,0.00007893951,0.00002614631,0.00002269457,0.0001625172,0.00003903101,0.0006099982],"genre_scores_gemma":[0.9968504,0.0008950685,0.000730929,0.00005362803,0.00001650668,0.00002543982,0.0003952173,0.000009224278,0.001023527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008986417,"threshold_uncertainty_score":0.00300622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006776457107246176,"score_gpt":0.23137110102567,"score_spread":0.2245946439184239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}