{"id":"W3045392621","doi":"10.1002/mc.23238","title":"Low‐dose triptolide enhances antitumor effect of JQ1 on acute myeloid leukemia through inhibiting RNA polymerase II in vitro and in vivo","year":2020,"lang":"en","type":"article","venue":"Molecular Carcinogenesis","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Infectious Diseases Centre","funders":"Natural Science Foundation of Fujian Province; National Natural Science Foundation of China","keywords":"Triptolide; Myeloid leukemia; In vivo; Cancer research; Leukemia; Apoptosis; Biology; Pharmacology; Cell culture; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001734014,0.0002738324,0.0003918547,0.0001057222,0.00005645932,0.00001710107,0.0001605604,0.0001544559,0.000008797707],"category_scores_gemma":[0.000164778,0.0002657264,0.0001326914,0.0003303113,0.00008587761,0.00001306957,0.0001703388,0.000124163,0.000001760696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003909082,"about_ca_system_score_gemma":0.00009202036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001199113,"about_ca_topic_score_gemma":0.0000144318,"domain_scores_codex":[0.9983572,0.0001983904,0.0003976782,0.000538459,0.000206286,0.0003020074],"domain_scores_gemma":[0.999478,0.00002027186,0.0001359937,0.0002341569,0.00002950666,0.0001021087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009305302,0.00003655837,0.0009283281,0.00008783012,0.00003398587,0.00007955485,0.0001173313,0.00005105006,0.9959416,0.000008920237,0.00004814346,0.001736187],"study_design_scores_gemma":[0.001849335,0.0006662994,0.0004789032,0.0000690905,0.00002826465,0.0000075869,0.00003438891,0.0001059756,0.9963204,0.000004831879,0.0001807221,0.0002542355],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969292,0.001789487,0.0002172546,0.0002584957,0.00005245297,0.0003985885,0.00003848522,0.00001238063,0.0003037144],"genre_scores_gemma":[0.9983123,0.0002439493,0.0003125658,0.00090622,0.00007036119,0.00004754647,0.00004739002,0.00003445892,0.00002522772],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001545538,"threshold_uncertainty_score":0.9999795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006776457107246176,"score_gpt":0.23137110102567,"score_spread":0.2245946439184239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}