{"id":"W3045402435","doi":"10.3390/biom10081097","title":"Protein–Protein Interactions Mediated by Intrinsically Disordered Protein Regions Are Enriched in Missense Mutations","year":2020,"lang":"en","type":"article","venue":"Biomolecules","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Missense mutation; Genetics; Biology; Protein–protein interaction; Mutation; Population; Computational biology; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008604379,0.0002464655,0.0002153314,0.00006663105,0.0001033427,0.00005957675,0.0002433391,0.0001932431,0.00002622409],"category_scores_gemma":[0.0002973075,0.0002431264,0.0001033088,0.0003415492,0.0001540926,0.00001078742,0.0001334891,0.0002192484,0.00004206413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002359432,"about_ca_system_score_gemma":0.00009433914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006946715,"about_ca_topic_score_gemma":0.0002417711,"domain_scores_codex":[0.9985977,0.00009470226,0.000444755,0.0003906641,0.0001393587,0.000332781],"domain_scores_gemma":[0.9991825,0.00001266803,0.0002054477,0.0003003493,0.00009037158,0.0002086157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001132354,0.0001428,0.00003890236,0.00003760598,0.00004821331,0.00001620776,0.0001862509,0.0000172262,0.9938962,0.0006181992,0.003774752,0.001110446],"study_design_scores_gemma":[0.006249215,0.001368526,0.0009760593,0.0003861268,0.00007524578,0.00005211326,0.002989545,0.007138072,0.7453148,0.003466289,0.229638,0.002345944],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9498879,0.0006946861,0.03206856,0.01463388,0.00005111754,0.001697047,0.0001888098,0.00007152323,0.0007064298],"genre_scores_gemma":[0.995784,0.00002195826,0.001938301,0.0006269569,0.0001051996,0.0002732461,0.0008156184,0.00003656584,0.000398121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2485813,"threshold_uncertainty_score":0.9914408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01023625369678425,"score_gpt":0.2293655474936142,"score_spread":0.21912929379683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}