{"id":"W3045459066","doi":"10.3389/fimmu.2020.01693","title":"Chronic Exposure of Gingival Fibroblasts to TLR2 or TLR4 Agonist Inhibits Osteoclastogenesis but Does Not Affect Osteogenesis","year":2020,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Oral microbiology and periodontitis research","field":"Dentistry","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Sahlgrenska Akademin; Göteborgs Universitet","keywords":"TLR2; RANKL; TLR4; Osteoclast; Bone resorption; Periodontitis; Chemistry; Toll-like receptor; Porphyromonas gingivalis; Peripheral blood mononuclear cell; Inflammation; Receptor; Cell biology; Agonist; Immunology; Endocrinology; Internal medicine; Innate immune system; Biology; Medicine; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001786245,0.0003541898,0.0003748803,0.0001623791,0.0001749743,0.0002942162,0.0001267808,0.0003273842,0.003432939],"category_scores_gemma":[0.0001388756,0.0001422356,0.0004096838,0.0001560966,0.0002242115,0.0001565205,0.0002320107,0.0006909852,0.0007701313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000131511,"about_ca_system_score_gemma":0.0004273113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001328349,"about_ca_topic_score_gemma":0.00249954,"domain_scores_codex":[0.9995773,0.00005708763,0.00004838219,0.00006047941,0.0001361507,0.0001205281],"domain_scores_gemma":[0.9998654,0.00003433957,0.00002301452,0.00002342664,0.00002156808,0.00003227024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004707067,0.0001340374,0.0003251601,0.0001246605,0.00001039465,0.00009981324,0.0000242087,0.00003500348,0.9962411,0.00003926306,0.0001584229,0.002337171],"study_design_scores_gemma":[0.0001070847,0.003847988,0.0170065,0.00003700836,0.00004817939,0.0007852982,0.0001957488,0.0003824365,0.9670147,0.00009936515,0.01046148,0.00001411715],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984507,0.008742305,0.001476159,0.0002578651,0.0002110197,0.00005074684,0.000958662,0.00005370173,0.003742587],"genre_scores_gemma":[0.9877379,0.003774216,0.001485004,0.0001626317,0.00004774447,0.00009678445,0.001075597,0.00001035001,0.005609754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003432939,"threshold_uncertainty_score":0.01148427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0184687374324638,"score_gpt":0.2670327093931958,"score_spread":0.248563971960732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}