{"id":"W3045469676","doi":"10.1158/1538-7445.pedca19-pr05","title":"Abstract PR05: T-cell receptor (TCR)-based immunotherapy in pediatric malignancy: Addressing the challenge of early metastasis and low immunogenicity","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Centre for Applied Research in Cancer Control; BC Cancer Agency; Ontario Institute for Cancer Research","funders":"","keywords":"T-cell receptor; Cancer research; Metastasis; Immunotherapy; Biology; Immunogenicity; CD8; T cell; Cancer; Cancer immunotherapy; Immunology; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001892226,0.0002512337,0.000195212,0.0001693541,0.0001046668,0.0002718831,0.0002646952,0.0002875992,0.002011721],"category_scores_gemma":[0.00008852364,0.00006375371,0.0001362887,0.0001226306,0.0001884063,0.0001874899,0.0001258408,0.0007368325,0.0005880584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003093362,"about_ca_system_score_gemma":0.0002460578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002222775,"about_ca_topic_score_gemma":0.0002502061,"domain_scores_codex":[0.9998935,0.000018895,0.000008741971,0.00001766944,0.00002729087,0.00003384833],"domain_scores_gemma":[0.9999313,0.00001000106,0.0000169065,0.000006137769,0.000008870712,0.0000268143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006302324,0.0001803308,0.0009873752,0.00008930897,0.0000114639,0.0002552444,0.0000179045,0.0002751642,0.9815674,0.0004186856,0.0008837839,0.01468311],"study_design_scores_gemma":[0.0002306617,0.003637999,0.01131357,0.00002295383,0.00006356683,0.003445768,0.00004161208,0.002060049,0.966162,0.0002336437,0.01278144,0.00000671216],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9872314,0.00354698,0.005198507,0.0006486351,0.00007107472,0.00005199486,0.0002676521,0.0001421643,0.002841587],"genre_scores_gemma":[0.9907515,0.001640899,0.003800104,0.0001701669,0.00004946673,0.00002698014,0.0004393959,0.00002118055,0.003100338],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.002011721,"threshold_uncertainty_score":0.006729841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1609360751923919,"score_gpt":0.4025395723156677,"score_spread":0.2416034971232758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}