{"id":"W3045476890","doi":"10.1128/iai.00303-20","title":"The <i>Salmonella</i> LysR Family Regulator RipR Activates the SPI-13-Encoded Itaconate Degradation Cluster","year":2020,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Operon; Biology; Isocitrate lyase; Glyoxylate cycle; Escherichia coli; Phagosome; Bacteria; Salmonella; Microbiology; lac operon; Biochemistry; Metabolite; Enterobacteriaceae; Gene; Enzyme; Phagocytosis; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001479334,0.000422545,0.0002471777,0.000174739,0.0001814992,0.0003911495,0.000198735,0.0002378182,0.002359028],"category_scores_gemma":[0.0001603306,0.0001343307,0.0003291414,0.0001194734,0.0002735558,0.0002094864,0.0005222143,0.0004680547,0.001521958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005123683,"about_ca_system_score_gemma":0.0002476939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005496539,"about_ca_topic_score_gemma":0.0005845604,"domain_scores_codex":[0.999791,0.00003359794,0.00001056819,0.00004577515,0.00005542006,0.00006365155],"domain_scores_gemma":[0.9998276,0.00002711562,0.00005161042,0.00002517917,0.00002935067,0.00003909306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005091303,0.000007321446,0.0001377546,0.00001203331,0.000001147584,0.00003599139,0.000006496334,0.00004015766,0.9990921,0.0001115665,0.00007356915,0.0004309225],"study_design_scores_gemma":[0.000007492217,0.00007782308,0.003729163,0.000004437442,0.000004165448,0.0001850383,0.00003426573,0.001447439,0.9922563,0.0000865344,0.002162249,0.000005139121],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748434,0.001047221,0.01319583,0.000408308,0.00008189736,0.00004481361,0.001060936,0.0009591669,0.008358263],"genre_scores_gemma":[0.9914744,0.0002879726,0.003256284,0.0001251489,0.00001312685,0.00002380378,0.000949588,0.000113102,0.003756474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002359028,"threshold_uncertainty_score":0.007891774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01192138436060482,"score_gpt":0.2183602360161786,"score_spread":0.2064388516555738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}