{"id":"W3045501231","doi":"10.1371/journal.pone.0234255","title":"Brain regions vulnerable and resistant to aging without Alzheimer’s disease","year":2020,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; Servier; Eisai; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Northern California Institute for Research and Education; F. Hoffmann-La Roche; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Disease; Alzheimer's disease; Neuroscience; Medicine; Gerontology; Biology; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000511594,0.0004571503,0.0005413205,0.0009885541,0.0003916197,0.0006848844,0.0002279642,0.0003391655,0.001455283],"category_scores_gemma":[0.000454432,0.0002164536,0.0002975619,0.0003905944,0.0007024843,0.0006335727,0.0005590151,0.0004567258,0.0002873117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002242656,"about_ca_system_score_gemma":0.0002708825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001101819,"about_ca_topic_score_gemma":0.002230355,"domain_scores_codex":[0.9998146,0.00001908729,0.00001748745,0.0000685528,0.00004017662,0.000040149],"domain_scores_gemma":[0.9997794,0.00001866622,0.00008144317,0.0000405393,0.00003621561,0.00004375224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001421661,0.0003123123,0.05199643,0.0003202004,0.0003448958,0.001619561,0.001194268,0.0002850134,0.9176561,0.001395178,0.0007423311,0.02271208],"study_design_scores_gemma":[0.00005914014,0.001520484,0.9237117,0.00006427799,0.000228062,0.005038131,0.0007588083,0.0003378809,0.06023049,0.002950004,0.005062793,0.00003833703],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945393,0.001585413,0.001316868,0.00008960029,0.00002743031,0.00002365208,0.000351203,0.0000419363,0.002024637],"genre_scores_gemma":[0.9959835,0.0008528188,0.001412052,0.0001412867,0.00002286089,0.00003269027,0.0003932127,0.00001489872,0.001146574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001455283,"threshold_uncertainty_score":0.004868388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1009017858832907,"score_gpt":0.3206540252382612,"score_spread":0.2197522393549705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}