{"id":"W3045544130","doi":"10.1016/j.virusres.2020.198087","title":"Interferon stimulated gene 15 promotes Zika virus replication through regulating Jak/STAT and ISGylation pathways","year":2020,"lang":"en","type":"article","venue":"Virus Research","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"National Key Research and Development Program of China; Chinese Academy of Medical Sciences Initiative for Innovative Medicine; National Natural Science Foundation of China","keywords":"ISG15; Zika virus; Biology; Interferon-stimulated gene; Virology; Interferon; Viral replication; JAK-STAT signaling pathway; Virus; Microcephaly; Gene; Immunology; Signal transduction; Genetics; Innate immune system; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008566638,0.0002171625,0.0001671037,0.0002130404,0.0001591337,0.0002640852,0.00008952981,0.0001467132,0.001696495],"category_scores_gemma":[0.00006752659,0.00008489163,0.0003440751,0.0001193187,0.0001972762,0.000199303,0.0002037782,0.0003796863,0.0002286015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002783545,"about_ca_system_score_gemma":0.0002046895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005426366,"about_ca_topic_score_gemma":0.0009019661,"domain_scores_codex":[0.9998969,0.00001468089,0.000008914029,0.00001477772,0.0000267306,0.00003800529],"domain_scores_gemma":[0.9999585,0.000005403419,0.00001378965,0.000002990225,0.000006312058,0.00001297675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003025089,0.00005203481,0.001458659,0.0001277663,0.00001223201,0.0001000467,0.00003220919,0.0001010634,0.9941978,0.0003693054,0.0001694605,0.003076948],"study_design_scores_gemma":[0.00007603665,0.000806353,0.07259418,0.00004664159,0.00005858535,0.0005528134,0.0001734354,0.003411231,0.9124286,0.0004128769,0.009422449,0.00001666359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862466,0.006642166,0.00173154,0.0002421858,0.0001062251,0.00003936858,0.0004976167,0.00006832832,0.00442602],"genre_scores_gemma":[0.9943786,0.001871058,0.001137357,0.00009739242,0.00001680066,0.00002062788,0.0005144993,0.000006186752,0.001957415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001696495,"threshold_uncertainty_score":0.005675375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1673372756048324,"score_gpt":0.3985180891765501,"score_spread":0.2311808135717177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}