{"id":"W3045544130","doi":"10.1016/j.virusres.2020.198087","title":"Interferon stimulated gene 15 promotes Zika virus replication through regulating Jak/STAT and ISGylation pathways","year":2020,"lang":"en","type":"article","venue":"Virus Research","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"National Key Research and Development Program of China; Chinese Academy of Medical Sciences Initiative for Innovative Medicine; National Natural Science Foundation of China","keywords":"ISG15; Zika virus; Biology; Interferon-stimulated gene; Virology; Interferon; Viral replication; JAK-STAT signaling pathway; Virus; Microcephaly; Gene; Immunology; Signal transduction; Genetics; Innate immune system; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006147755,0.0001658765,0.0002941959,0.0001002393,0.0002420419,0.0001053988,0.0001360561,0.0001218922,0.0002419041],"category_scores_gemma":[0.0009258778,0.0001458321,0.00006853841,0.0005260085,0.0001103911,0.0002008372,0.0001574585,0.0003991124,0.0001008463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009314164,"about_ca_system_score_gemma":0.000135917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004504186,"about_ca_topic_score_gemma":0.00003051807,"domain_scores_codex":[0.9976015,0.0002112445,0.0003737844,0.0007132903,0.0006645917,0.0004356079],"domain_scores_gemma":[0.9984667,0.0001578135,0.00008559422,0.0005956285,0.0003939696,0.0003003457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002285303,0.0001521795,0.001751842,0.0002062461,0.0000732625,0.00003296098,0.001979308,0.00003805684,0.9142328,0.0003939644,0.001612783,0.07724131],"study_design_scores_gemma":[0.007564785,0.005146483,0.04994272,0.0004409699,0.0002035918,0.00003264081,0.00106803,0.2516299,0.6651698,0.002627308,0.01554719,0.0006265601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897993,0.002122295,0.001155629,0.004609996,0.00002595696,0.00130171,0.00004179625,0.0001377948,0.0008054859],"genre_scores_gemma":[0.9977168,0.0002441246,0.0006374186,0.0006144029,0.0003180559,0.00008866795,0.0001493254,0.00004360504,0.0001876152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2515918,"threshold_uncertainty_score":0.594686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1673372756048324,"score_gpt":0.3985180891765501,"score_spread":0.2311808135717177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}