{"id":"W3045548795","doi":"10.1210/clinem/dgaa484","title":"International Histopathology Consensus for Unilateral Primary Aldosteronism","year":2020,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":289,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; European Research Council; U.S. Department of Veterans Affairs; Else Kröner-Fresenius-Stiftung; Deutsche Forschungsgemeinschaft; Japan Society for the Promotion of Science","keywords":"Primary aldosteronism; Histopathology; Medicine; Hyperaldosteronism; Aldosterone synthase; Pathology; H&E stain; Aldosterone; Immunohistochemistry; Internal medicine; Blood pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008257486,0.0001278785,0.0008577753,0.00007406855,0.00005966402,0.000006091423,0.0002560968,0.0001258767,0.0001033396],"category_scores_gemma":[0.001539751,0.00007593941,0.0003843028,0.0000559076,0.0003541333,0.00004272808,0.00007641742,0.00062673,0.00002338011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001907012,"about_ca_system_score_gemma":0.000215824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001780889,"about_ca_topic_score_gemma":3.538863e-7,"domain_scores_codex":[0.9978257,0.0003047845,0.001248018,0.0001420875,0.000252336,0.00022704],"domain_scores_gemma":[0.997705,0.0008188984,0.0005972869,0.0001601569,0.0004958384,0.0002228556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.06727842,0.001505448,0.01968845,0.0001203978,0.002482907,0.003693572,0.002199395,0.0001666103,0.1683354,0.03199738,0.112022,0.59051],"study_design_scores_gemma":[0.006698511,0.0007035219,0.1747114,0.00001182502,0.0005089879,0.004099428,0.00004570586,0.0003150705,0.0003523979,0.0005259987,0.8119586,0.00006851453],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7304081,0.001753144,0.0009669426,0.2631496,0.002032523,0.0002320107,0.000006437891,0.00002122876,0.00143007],"genre_scores_gemma":[0.9494419,0.001440553,0.00475722,0.04051341,0.003180807,0.000002293956,0.000007922178,0.00002206147,0.0006337992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6999366,"threshold_uncertainty_score":0.3096719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1236624693914792,"score_gpt":0.3928825229794885,"score_spread":0.2692200535880093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}