{"id":"W3045591679","doi":"10.1016/j.colsurfb.2020.111287","title":"Mucus-penetrating PEGylated polysuccinimide-based nanocarrier for intravaginal delivery of siRNA battling sexually transmitted infections","year":2020,"lang":"en","type":"article","venue":"Colloids and Surfaces B Biointerfaces","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Research Manitoba","keywords":"Nanocarriers; Polyethylene glycol; PEG ratio; PEGylation; Chemistry; HeLa; Mucus; Combinatorial chemistry; Drug delivery; In vitro; Biology; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001536122,0.0002570375,0.0003076964,0.00006156267,0.0001542615,0.00006808926,0.0001910581,0.0001701107,0.00002761936],"category_scores_gemma":[0.00008519018,0.0002412898,0.0001092321,0.0001621811,0.0001523274,0.00001703434,0.00005309983,0.0001057103,0.000001777879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007734847,"about_ca_system_score_gemma":0.0001569435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008049657,"about_ca_topic_score_gemma":0.0001254111,"domain_scores_codex":[0.9986429,0.00006066167,0.0004249659,0.0004718962,0.0001182933,0.0002813238],"domain_scores_gemma":[0.9992493,0.00006943716,0.0001454482,0.0001638905,0.000225205,0.0001466624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003906718,0.00005628377,0.0110696,0.0001188045,0.0001483201,0.000001100979,0.0002688487,0.001118354,0.9840906,0.00000657395,0.0004146796,0.002316161],"study_design_scores_gemma":[0.001266069,0.003540385,0.001611268,0.00007554313,0.00007889362,0.000005228649,0.0007488452,0.009406201,0.9797956,0.000012081,0.003103468,0.0003564268],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897383,0.002506873,0.006503708,0.0004382856,0.0001446254,0.0003349969,0.0001627062,0.00003033063,0.0001401635],"genre_scores_gemma":[0.9973707,0.0002509002,0.001708562,0.0003634862,0.00007924112,0.00001854955,0.00007975987,0.00002829678,0.0001005113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009458329,"threshold_uncertainty_score":0.9839513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01544571487019444,"score_gpt":0.2445782570576699,"score_spread":0.2291325421874755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}