{"id":"W3045596417","doi":"10.1101/2020.07.28.225888","title":"SMAD2 Promotes Myogenin Expression and Terminal Myogenic Differentiation","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; King Saud University; University of Ottawa","keywords":"Myogenin; Myogenesis; Myostatin; Myogenic regulatory factors; Myocyte; Cell biology; C2C12; MYF5; MyoD; Smad2 Protein; Biology; Cellular differentiation; Transforming growth factor; Transcription factor; Transforming growth factor beta; Skeletal muscle; Endocrinology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001805334,0.0003681254,0.000183141,0.0003676125,0.0002043568,0.0002960658,0.0001260419,0.0002515962,0.00485444],"category_scores_gemma":[0.00008790837,0.0001888668,0.0002899424,0.0001362073,0.0001903119,0.0001450394,0.0003606122,0.0005076256,0.00168101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002360365,"about_ca_system_score_gemma":0.000207985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003041632,"about_ca_topic_score_gemma":0.0005573739,"domain_scores_codex":[0.9998748,0.00001639206,0.00000676941,0.00002409682,0.00004742698,0.00003045031],"domain_scores_gemma":[0.9998991,0.00001209077,0.00001921048,0.00001001317,0.00001551964,0.00004399482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008998327,0.00001229348,0.0001186061,0.00003224809,0.000003321888,0.00005044231,0.000006116487,0.00003198841,0.9987894,0.0001578063,0.0001193066,0.0005884085],"study_design_scores_gemma":[0.0000243053,0.00008580617,0.005617987,0.000009130218,0.000007822891,0.0002961817,0.00001993926,0.0006588796,0.9873576,0.0001110106,0.0058079,0.000003489723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9665847,0.004519054,0.01203851,0.0005007872,0.0002132059,0.00005503085,0.00195086,0.0003355393,0.01380236],"genre_scores_gemma":[0.9639784,0.001477594,0.003981829,0.0001673381,0.0000733866,0.00004076909,0.002266391,0.0001234403,0.02789092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00485444,"threshold_uncertainty_score":0.0162397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01075273888707911,"score_gpt":0.2156155046610093,"score_spread":0.2048627657739301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}