{"id":"W3045600614","doi":"10.1158/1078-0432.ccr-19-2303","title":"Copy Number Loss of 17q22 Is Associated with Enzalutamide Resistance and Poor Prognosis in Metastatic Castration-Resistant Prostate Cancer","year":2020,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute; Stand Up To Cancer; National Institutes of Health; U.S. National Library of Medicine; U.S. Department of Defense","keywords":"Enzalutamide; Prostate cancer; Biology; Cancer research; Transcriptome; Cancer; Internal medicine; Androgen receptor; Gene; Medicine; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001833608,0.000211208,0.0002369624,0.0005014507,0.0001095634,0.0002212218,0.00014741,0.0001526746,0.0008320165],"category_scores_gemma":[0.0004915515,0.0001222744,0.0001273223,0.0003274048,0.0001818753,0.00009005005,0.0001502698,0.0001569611,0.00009384115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001658622,"about_ca_system_score_gemma":0.0001036707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001217466,"about_ca_topic_score_gemma":0.001620625,"domain_scores_codex":[0.9999009,0.0000187589,0.000007167273,0.00002737944,0.00002984006,0.00001602065],"domain_scores_gemma":[0.9996513,0.00005304426,0.0002096875,0.00001831142,0.00002820008,0.00003933206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001272711,0.00003918112,0.8863552,0.00004965225,0.0001851366,0.000442559,0.00007088514,0.0003408119,0.1040296,0.0000184442,0.00007884111,0.007117073],"study_design_scores_gemma":[0.00001438718,0.0001413011,0.9942696,0.000003076426,0.00004984647,0.0008421461,0.00003322283,0.0004287029,0.004042619,0.00001603221,0.0001560478,0.000003042307],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995284,0.0002745675,0.00008438765,0.000008199785,6.042271e-7,0.000001867591,0.00005473255,0.000003288852,0.00004401997],"genre_scores_gemma":[0.9996425,0.00008011313,0.00007180795,0.000006100719,0.000001512014,0.000002344467,0.0001354062,0.000001229087,0.00005904226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001217466,"threshold_uncertainty_score":0.002783418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2182588947202795,"score_gpt":0.504447810987608,"score_spread":0.2861889162673286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}