{"id":"W3045625371","doi":"10.7554/elife.56428","title":"A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution","year":2020,"lang":"en","type":"article","venue":"eLife","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Australian Research Council; Cancer Council NSW; Natural Sciences and Engineering Research Council of Canada; Center of Excellence for Innovation in Chemistry; Cancer Institute NSW","keywords":"Telomerase; Telomere; Förster resonance energy transfer; Ribonucleoprotein; G-quadruplex; RNA; Telomerase RNA component; DNA; Chemistry; Biophysics; Telomerase reverse transcriptase; Biology; Biochemistry; Fluorescence; Gene; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001101328,0.0001222149,0.0001516375,0.00001893406,0.000185839,0.00001147742,0.0000869321,0.00008451335,9.091593e-7],"category_scores_gemma":[0.0001444347,0.00008899641,0.00008251235,0.00008689152,0.00009400272,0.00000298806,0.0001086075,0.0000418189,3.384917e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009663854,"about_ca_system_score_gemma":0.000008117539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001085407,"about_ca_topic_score_gemma":0.000008071434,"domain_scores_codex":[0.9992207,0.00002909944,0.0001939513,0.0002941472,0.0001139543,0.0001481024],"domain_scores_gemma":[0.9995062,0.00002158318,0.0001276943,0.0001884123,0.00009852344,0.00005762149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000793231,0.00002170119,0.00003171738,0.00001407451,0.00003307267,5.063843e-7,0.00002392181,0.000007163936,0.995342,0.0001338092,0.003604388,0.0007083671],"study_design_scores_gemma":[0.0002632717,0.0003975024,0.00003822392,0.00001133586,0.00004760145,0.000004225646,0.00006649952,0.0008751831,0.9922541,0.00006092197,0.005858356,0.0001227709],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9594029,0.001442734,0.03767064,0.001094642,0.00001923738,0.0002621402,0.00003433028,0.00003539073,0.00003798204],"genre_scores_gemma":[0.9914995,0.0003534806,0.006826018,0.001019269,0.00008218311,0.00001236782,0.00008953505,0.00001645537,0.0001011369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03209665,"threshold_uncertainty_score":0.3629168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02269456356935027,"score_gpt":0.2759549011493223,"score_spread":0.253260337579972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}