{"id":"W3045647287","doi":"10.1016/j.joca.2020.07.003","title":"Sequencing identifies a distinct signature of circulating microRNAs in early radiographic knee osteoarthritis","year":2020,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Public Health Ontario; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Krembil Foundation","keywords":"MiRBase; microRNA; Osteoarthritis; Gene expression profiling; Gene; Bioinformatics; Biology; Oncology; Computational biology; Medicine; Gene expression; Genetics; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001857025,0.0003539169,0.0007909202,0.0002280064,0.0001219735,0.00007692975,0.00008966132,0.0002286198,0.00008457043],"category_scores_gemma":[0.0001038166,0.0003698982,0.0002548167,0.0005953067,0.0001980243,0.0002701992,0.00008853721,0.0003680606,0.00001299555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004085637,"about_ca_system_score_gemma":0.00008052288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003879982,"about_ca_topic_score_gemma":0.0002835565,"domain_scores_codex":[0.9977541,0.00009260626,0.0006654479,0.0006048969,0.0003759636,0.0005069603],"domain_scores_gemma":[0.9990248,0.00006605625,0.0001846145,0.0002774159,0.0001027391,0.0003443657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000252987,0.00004414568,0.04085783,0.0002517619,0.00001020534,0.001693992,0.003618145,0.000001326007,0.9003264,0.0002158337,0.00002069568,0.05270663],"study_design_scores_gemma":[0.04324694,0.02775309,0.03097365,0.00632982,0.0006393355,0.00204426,0.007978401,0.00004202426,0.8763568,0.001068944,0.001692768,0.001874002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826106,0.01428079,0.000009479367,0.0002469353,0.0001530493,0.0008467961,0.00008993193,0.00009335523,0.001669103],"genre_scores_gemma":[0.9988465,0.0001324457,0.0003151497,0.0002605318,0.0001551094,0.00006441829,0.0000667628,0.0000575179,0.0001015054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05083262,"threshold_uncertainty_score":0.9998753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01256002293274158,"score_gpt":0.2185552696864398,"score_spread":0.2059952467536983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}