{"id":"W3045664325","doi":"10.1093/humrep/deaa151","title":"Periconceptional exposure to lopinavir, but not darunavir, impairs decidualization: a potential mechanism leading to poor birth outcomes in HIV-positive pregnancies","year":2020,"lang":"en","type":"article","venue":"Human Reproduction","topic":"HIV-related health complications and treatments","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Toronto General Hospital; University Health Network","funders":"Toronto General Hospital Research Institute, University Health Network; Canadian Institutes of Health Research","keywords":"Darunavir; Lopinavir; Decidualization; Medicine; Pregnancy; Mechanism (biology); Obstetrics; Human immunodeficiency virus (HIV); Antiretroviral therapy; Biology; Immunology; Viral load","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001417853,0.0002106971,0.0003522912,0.0002359684,0.0003119877,0.00003668216,0.00008853123,0.00009053227,0.000164163],"category_scores_gemma":[0.0001482643,0.0002045134,0.00008049306,0.0005399227,0.00003171902,0.0001324475,0.00006379587,0.0001880699,0.0003928498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000292037,"about_ca_system_score_gemma":0.00009778412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007093704,"about_ca_topic_score_gemma":0.00001826174,"domain_scores_codex":[0.9979849,0.0000634943,0.000468814,0.0008433713,0.0003484919,0.0002908952],"domain_scores_gemma":[0.9989911,0.00001338776,0.0001069713,0.0003929658,0.0002189356,0.0002765995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002901762,0.003940248,0.2643829,0.0009109908,0.0007385568,0.0004843114,0.06342091,0.01093982,0.570016,0.0507223,0.00701655,0.0245256],"study_design_scores_gemma":[0.003345582,0.003174877,0.9714043,0.0005706631,0.0001544361,0.0001480897,0.001917001,0.0002206507,0.01538116,0.0003762999,0.002785496,0.0005214901],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9667026,0.00009400884,0.005762103,0.02527713,0.0002098174,0.001526792,0.00004864352,0.0001663162,0.0002125623],"genre_scores_gemma":[0.9913421,0.00001314461,0.003184092,0.001740974,0.0003735532,0.0002487496,0.0002116087,0.00003554413,0.002850285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7070213,"threshold_uncertainty_score":0.8339816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0366712140405854,"score_gpt":0.3227568791733387,"score_spread":0.2860856651327532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}