{"id":"W3045696640","doi":"10.1038/s41586-020-2449-8","title":"Perspectives on ENCODE","year":2020,"lang":"en","type":"article","venue":"Nature","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":227,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; McGill University; Simon Fraser University; Université de Montréal; Montreal Clinical Research Institute","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Institutes of Health; National Cancer Institute; National Human Genome Research Institute; Biotechnology and Biological Sciences Research Council","keywords":"ENCODE; Human genome; Gene; Biology; Genome; Chromatin; Computational biology; Genetics; Transcription factor; Histone; Evolutionary biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003958602,0.0006236961,0.0006197008,0.0007641522,0.001338781,0.004265652,0.001118643,0.0027287,0.02772003],"category_scores_gemma":[0.007046609,0.0002580507,0.0003655613,0.001137756,0.006100987,0.008777839,0.002889088,0.005077305,0.004791705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001990633,"about_ca_system_score_gemma":0.00258592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002486791,"about_ca_topic_score_gemma":0.00321064,"domain_scores_codex":[0.9987162,0.0004679917,0.00005225006,0.0001863079,0.0003531849,0.0002240272],"domain_scores_gemma":[0.9955097,0.001844065,0.0001212609,0.0009633041,0.0006750382,0.000886591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005475816,0.00001022063,0.0001293584,0.00008532683,0.000005414196,0.00004737401,0.0002690363,0.0001571322,0.001060098,0.8946263,0.06623098,0.03732402],"study_design_scores_gemma":[0.000008041844,0.00001239622,0.0001012822,0.00009134926,0.000004822409,0.00009232228,0.0002694688,0.000136467,0.0007187763,0.267754,0.7308026,0.000008444974],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.007187691,0.06478624,0.04232131,0.5198243,0.02863465,0.00003048478,0.001794808,0.0007903146,0.3346303],"genre_scores_gemma":[0.288659,0.1693172,0.04506046,0.185691,0.0289046,0.000343873,0.00465137,0.001568494,0.275804],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02772003,"threshold_uncertainty_score":0.09273273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003880823790593115,"score_gpt":0.2241235649243367,"score_spread":0.2202427411337435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}