{"id":"W3045709265","doi":"10.1016/j.bone.2020.115547","title":"Assessment of longitudinal bone growth in osteogenesis imperfecta using metacarpophalangeal pattern profiles","year":2020,"lang":"en","type":"article","venue":"Bone","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Shriners Hospitals for Children - Canada; Children's Hospital of Eastern Ontario; McGill University; Montreal Children's Hospital","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Rare Diseases Clinical Research Network; National Institutes of Health; National Institute of Dental and Craniofacial Research; Mereo BioPharma; Osteogenesis Imperfecta Foundation","keywords":"Osteogenesis imperfecta; Haploinsufficiency; Short stature; Medicine; Type I collagen; Bone age; Bone density; Internal medicine; Anatomy; Biology; Phenotype; Osteoporosis; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003427599,0.0002136752,0.0002477255,0.001913082,0.0001864157,0.0004310251,0.000215121,0.0002866583,0.001403444],"category_scores_gemma":[0.001050284,0.000185986,0.0001946577,0.001268971,0.0001744008,0.0002426394,0.0003939166,0.0002292959,0.0003927673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001899902,"about_ca_system_score_gemma":0.0002277445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007647043,"about_ca_topic_score_gemma":0.01174456,"domain_scores_codex":[0.9997801,0.00003821655,0.00002085035,0.000040463,0.00008755167,0.00003280521],"domain_scores_gemma":[0.9993669,0.0001382603,0.0001708568,0.00004241682,0.0002030276,0.00007851769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001684536,0.00007072997,0.7198167,0.0001398997,0.0001124791,0.001076519,0.0003260477,0.001517939,0.2062849,0.0001386742,0.0001905245,0.06864113],"study_design_scores_gemma":[0.000008323204,0.000248469,0.969011,0.00002195903,0.0000675853,0.003247379,0.0003175519,0.003781338,0.02255949,0.00007939426,0.0006406161,0.00001689046],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930055,0.0005173846,0.003726884,0.00002027993,0.000004494506,0.00003050955,0.0009102379,0.00004808981,0.001736719],"genre_scores_gemma":[0.9953381,0.0002703816,0.003134641,0.000007065313,0.000003208357,0.00002128217,0.0002837204,0.0000155202,0.0009260319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007647043,"threshold_uncertainty_score":0.01520503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03904825614122674,"score_gpt":0.3309036508868503,"score_spread":0.2918553947456236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}