{"id":"W3045754390","doi":"10.1007/s10637-020-00906-5","title":"Novel Bacillus strains from the human gut exert anticancer effects on a broad range of malignancy types","year":2020,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Natural Science Foundation of China","keywords":"Biology; Colorectal cancer; Flow cytometry; Cancer; Microbiology; Apoptosis; Malignancy; Bacteria; Cancer cell; Bacillus (shape); Ovarian cancer; Cancer research; Gut flora; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001527642,0.0003020525,0.0003521196,0.0002871764,0.000102895,0.0002455443,0.0001087187,0.0002251994,0.001443424],"category_scores_gemma":[0.000257824,0.0001063184,0.0002504631,0.0002516074,0.0002027711,0.0001165051,0.0002252758,0.0007057791,0.0003844328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001065892,"about_ca_system_score_gemma":0.0002021183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003016533,"about_ca_topic_score_gemma":0.0005945145,"domain_scores_codex":[0.99989,0.00002028782,0.00001048323,0.00001645445,0.0000374642,0.00002539063],"domain_scores_gemma":[0.9998827,0.00002429895,0.00002296668,0.00001576793,0.00001978262,0.00003442141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005402958,0.0001057199,0.0009193616,0.0001574659,0.00001525939,0.0001506996,0.00003119554,0.000112601,0.9833586,0.0002165832,0.0002343992,0.01415793],"study_design_scores_gemma":[0.0001283993,0.0029134,0.01039086,0.00004341503,0.00007932465,0.002015861,0.0001022264,0.0004385708,0.9714502,0.0001723153,0.01225274,0.00001271026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786736,0.01043762,0.0040089,0.0005028868,0.000203954,0.00008143813,0.0009290107,0.000131833,0.005030676],"genre_scores_gemma":[0.980204,0.007999066,0.005782216,0.0001842268,0.00009484809,0.00005050895,0.001802291,0.00005079647,0.00383201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001443424,"threshold_uncertainty_score":0.004828691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02882729886213979,"score_gpt":0.2844492380879273,"score_spread":0.2556219392257875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}