{"id":"W3045756317","doi":"10.3389/fcimb.2020.00380","title":"Immunomodulatory Properties of Leishmania Extracellular Vesicles During Host-Parasite Interaction: Differential Activation of TLRs and NF-κB Translocation by Dermotropic and Viscerotropic Species","year":2020,"lang":"en","type":"article","venue":"Frontiers in Cellular and Infection Microbiology","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Fundação de Amparo à Pesquisa do Estado de Minas Gerais; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Chromosomal translocation; Extracellular vesicles; Cell biology; Extracellular; Leishmania; Parasite hosting; Biology; NF-κB; Host (biology); Differential (mechanical device); Immune system; Signal transduction; Microbiology; Chemistry; Immunology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007536522,0.0001540535,0.0004215155,0.0001799373,0.00008054529,0.00001389177,0.00003214168,0.0001160077,0.00001409439],"category_scores_gemma":[0.00004067218,0.0001396636,0.00004284818,0.0001138224,0.0003759866,0.0001677304,0.0000439026,0.0002014339,3.052948e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004224689,"about_ca_system_score_gemma":0.00001715192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008873649,"about_ca_topic_score_gemma":0.000005697917,"domain_scores_codex":[0.9990005,0.0001376963,0.0003641521,0.0002793023,0.00006155643,0.0001567148],"domain_scores_gemma":[0.9996303,0.00001488314,0.000139164,0.00009036824,0.00007519177,0.00005009547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002946047,0.0000677976,0.1711064,0.0005153071,0.00011472,0.000001216106,0.0009723405,0.00000344476,0.8252007,0.000006545011,0.0000732596,0.001643654],"study_design_scores_gemma":[0.00147565,0.0003199552,0.2030071,0.0001352443,0.00003852208,0.00001851962,0.0004235466,0.0002674325,0.7938588,0.000004653347,0.0003566019,0.00009401429],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820806,0.008643925,0.008358386,0.0003761987,0.0001223088,0.0003853608,0.000006605756,0.00001580446,0.00001075603],"genre_scores_gemma":[0.9956089,0.004024528,0.0002032322,0.00001707212,0.00004667097,0.00001226946,0.0000261146,0.00001366993,0.00004752395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0319007,"threshold_uncertainty_score":0.5695317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01614494909165292,"score_gpt":0.2241462529874273,"score_spread":0.2080013038957744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}