{"id":"W3045756317","doi":"10.3389/fcimb.2020.00380","title":"Immunomodulatory Properties of Leishmania Extracellular Vesicles During Host-Parasite Interaction: Differential Activation of TLRs and NF-κB Translocation by Dermotropic and Viscerotropic Species","year":2020,"lang":"en","type":"article","venue":"Frontiers in Cellular and Infection Microbiology","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Fundação de Amparo à Pesquisa do Estado de Minas Gerais; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Chromosomal translocation; Extracellular vesicles; Cell biology; Extracellular; Leishmania; Parasite hosting; Biology; NF-κB; Host (biology); Differential (mechanical device); Immune system; Signal transduction; Microbiology; Chemistry; Immunology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000177796,0.0002339896,0.000166067,0.0001412086,0.00009503154,0.0002389761,0.00008805,0.0002189384,0.0005698055],"category_scores_gemma":[0.000143925,0.00008832625,0.0002453475,0.00008049879,0.0001471137,0.0002566487,0.0002056077,0.0002035226,0.0001237858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001048437,"about_ca_system_score_gemma":0.00008172824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001297827,"about_ca_topic_score_gemma":0.0001813498,"domain_scores_codex":[0.9998741,0.00002912425,0.00001014587,0.00002446071,0.00001992272,0.00004224593],"domain_scores_gemma":[0.9999442,0.00001035237,0.00001479527,0.000005427155,0.0000114194,0.00001377223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001902966,0.00001321068,0.0006011474,0.00006022873,0.000004692571,0.00007235247,0.00003211357,0.00002629987,0.998016,0.00003286101,0.000009777454,0.0009410979],"study_design_scores_gemma":[0.00005339001,0.0009064507,0.05263435,0.0000427612,0.00005642767,0.001617796,0.0002540041,0.001363468,0.9398073,0.000190576,0.003058747,0.00001463104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971884,0.001697099,0.0005633466,0.00003291493,0.00001012224,0.000009915159,0.00009098971,0.000006048716,0.0004012403],"genre_scores_gemma":[0.9985884,0.0004700164,0.0004031709,0.0000342205,0.000006050136,0.00001487713,0.0001586842,0.000003693242,0.000320816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005698055,"threshold_uncertainty_score":0.001906157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01614494909165292,"score_gpt":0.2241462529874273,"score_spread":0.2080013038957744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}