{"id":"W3045850890","doi":"10.1101/2020.06.26.20138172","title":"ASSESSING THE RELATIONSHIP BETWEEN MONOALLELIC <i>PARK2</i> MUTATIONS AND PARKINSON’S RISK","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; Medical Research Council; Michael J. Fox Foundation for Parkinson's Research; Parkinson Vereniging; McGill University; Deutsche Forschungsgemeinschaft; Wellcome Trust; University College London; Parkinson's UK; Multiple System Atrophy Coalition; National Institute for Health and Care Research; National Institute on Aging; Canada First Research Excellence Fund; American Parkinson Disease Association; Consortium canadien en neurodégénérescence associée au vieillissement; Agence Nationale de la Recherche; University of Dundee; National Institutes of Health; U.S. Department of Health and Human Services; U.S. Department of Defense; National Institute of Neurological Disorders and Stroke; Fondation de France; Bundesministerium für Bildung und Forschung; EU Joint Programme – Neurodegenerative Disease Research","keywords":"Genetics; Mutation; Biology; Allele; Parkin; Confounding; Internal medicine; Medicine; Parkinson's disease; Gene; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01154167,0.0008587668,0.001419284,0.002285275,0.0003746624,0.001771256,0.0009969444,0.001523368,0.003495131],"category_scores_gemma":[0.02073478,0.0005125219,0.005531298,0.002621333,0.0005457532,0.0007529376,0.000876506,0.001246737,0.0002886163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002643162,"about_ca_system_score_gemma":0.0003196452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001694376,"about_ca_topic_score_gemma":0.002004847,"domain_scores_codex":[0.9922758,0.003778947,0.0009825337,0.001938934,0.000798287,0.000225476],"domain_scores_gemma":[0.9690195,0.02395688,0.00379896,0.00171986,0.001031906,0.0004728707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00505231,0.000087455,0.8563672,0.002799566,0.1159632,0.0002458274,0.00009989503,0.0008523831,0.002253818,0.0003360561,0.0007946982,0.01514762],"study_design_scores_gemma":[0.0008678784,0.001777103,0.7928616,0.0008620201,0.1872016,0.001122716,0.0002211327,0.005979789,0.002372411,0.002274261,0.004403148,0.00005620739],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8354807,0.1432817,0.01153811,0.001728114,0.0006395155,0.0001673689,0.003397021,0.0001261239,0.003641124],"genre_scores_gemma":[0.9946302,0.003230485,0.0009775923,0.0002407261,0.0001689019,0.00003942391,0.0004353122,0.00001783294,0.0002593931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01154167,"threshold_uncertainty_score":0.06103891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09349056907280195,"score_gpt":0.3475959256507462,"score_spread":0.2541053565779442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}