{"id":"W3045852567","doi":"10.1039/d0cb00045k","title":"Glycosylated cyclophellitol-derived activity-based probes and inhibitors for cellulases","year":2020,"lang":"en","type":"article","venue":"RSC Chemical Biology","topic":"Biofuel production and bioconversion","field":"Engineering","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 European Research Council; Biotechnology and Biological Sciences Research Council; Royal Society; Directorate for Biological Sciences; Natural Sciences and Engineering Research Council of Canada; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Diamond Light Source","keywords":"Cellulase; Chemistry; Enzyme; Biochemistry; Glucanase; Chromogenic; Glucosidases; Chromatography","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002015156,0.0007693216,0.000167745,0.0001650925,0.0001189062,0.000309492,0.0003341155,0.0005170933,0.001654516],"category_scores_gemma":[0.0003313254,0.0001938053,0.0001876694,0.0001804539,0.0002761058,0.0003615314,0.0002842463,0.001214253,0.0006726522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003850128,"about_ca_system_score_gemma":0.0002164625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003899418,"about_ca_topic_score_gemma":0.0006058314,"domain_scores_codex":[0.999798,0.00005176564,0.00001009555,0.00004888422,0.00004755676,0.00004365536],"domain_scores_gemma":[0.9998145,0.00004981071,0.00005652534,0.00002810204,0.00002235901,0.00002880162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005204454,0.00001425495,0.0000471266,0.00005649365,0.000004277738,0.00004419393,0.0000127426,0.000140706,0.9964978,0.000497631,0.0001633227,0.002469408],"study_design_scores_gemma":[0.000004414178,0.00003885171,0.0002008147,0.000003046545,0.000003240644,0.00007873052,0.000003797711,0.0003486392,0.9959926,0.00003694078,0.003284873,0.000004096561],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7286153,0.007629176,0.2348699,0.001109605,0.0002561007,0.0005033955,0.002477514,0.001070091,0.02346876],"genre_scores_gemma":[0.9236594,0.005081363,0.05574332,0.0006318624,0.00005854563,0.0004123989,0.002751952,0.0001507939,0.01151035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001654516,"threshold_uncertainty_score":0.005534887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01495776219147422,"score_gpt":0.2113730041880273,"score_spread":0.1964152419965531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}