{"id":"W3045909440","doi":"10.1016/j.jcf.2020.07.015","title":"Emerging preclinical modulators developed for F508del-CFTR have the potential to be effective for ORKAMBI resistant processing mutants","year":2020,"lang":"en","type":"article","venue":"Journal of Cystic Fibrosis","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Hospital for Sick Children; Ontario Genomics Institute; Government of Canada; Government of Ontario; Canadian Institutes of Health Research; Genome Canada; Ontario Genomics; Cystic Fibrosis Canada","keywords":"Potentiator; Ivacaftor; HEK 293 cells; Mutant; Cystic fibrosis; Medicine; Cell biology; Pharmacology; Biology; Cell culture; Cystic fibrosis transmembrane conductance regulator; Genetics; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008258554,0.0007065221,0.0008211613,0.0002664758,0.0003042972,0.0008131384,0.0006481292,0.0009098484,0.005998488],"category_scores_gemma":[0.0006230281,0.0001875349,0.0005766815,0.0001586743,0.0005442088,0.0006982401,0.0002504572,0.00261368,0.0009176911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000396846,"about_ca_system_score_gemma":0.0005904065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006749128,"about_ca_topic_score_gemma":0.001418089,"domain_scores_codex":[0.9997903,0.00006701744,0.0000115451,0.00002727493,0.00003863639,0.00006526713],"domain_scores_gemma":[0.9997173,0.00007336609,0.00006917537,0.00002653563,0.00004186937,0.00007182223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00530942,0.002040996,0.0008430614,0.001034898,0.0001201044,0.0005658484,0.0001598328,0.0008161664,0.9202615,0.003207829,0.006197176,0.05944312],"study_design_scores_gemma":[0.007800995,0.07846075,0.01170225,0.0004049279,0.000664105,0.002352972,0.0002832211,0.003148867,0.7630744,0.002144621,0.1298734,0.00008945232],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8886625,0.05484445,0.02261179,0.005236574,0.002191576,0.002544684,0.002894158,0.001307604,0.0197066],"genre_scores_gemma":[0.947315,0.02650695,0.01163254,0.001390702,0.0004171045,0.0008282678,0.00302671,0.0001602811,0.008722389],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005998488,"threshold_uncertainty_score":0.02006698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0408741864108789,"score_gpt":0.3709982692946566,"score_spread":0.3301240828837777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}