{"id":"W3045923623","doi":"10.1021/acs.biochem.0c00478","title":"Potent Inhibition of Mandelate Racemase by Boronic Acids: Boron as a Mimic of a Carbon Acid Center","year":2020,"lang":"en","type":"article","venue":"Biochemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Phenylboronic acid; Boronic acid; Hydrolysis; Substrate (aquarium); Active site; Stereochemistry; Catalysis; Boron; Medicinal chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003094371,0.000431143,0.0004145148,0.0001108522,0.0001116308,0.0002206467,0.0003156349,0.0003123167,0.0005721074],"category_scores_gemma":[0.0001915295,0.0001540248,0.0002310976,0.0001197672,0.0002327472,0.0001654392,0.0002388772,0.0004557178,0.0002018384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002421262,"about_ca_system_score_gemma":0.0001832757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000689534,"about_ca_topic_score_gemma":0.001447925,"domain_scores_codex":[0.999803,0.00004523282,0.0000167982,0.00004001765,0.00005510672,0.00003987947],"domain_scores_gemma":[0.9999223,0.00001931867,0.00002096522,0.000007908371,0.000009654746,0.00001988001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006325029,0.00001685696,0.0000514441,0.00002508331,0.000003982776,0.00001560418,0.000006546099,0.00006037117,0.9992674,0.00003838355,0.00001289745,0.0004382235],"study_design_scores_gemma":[0.000008012322,0.0001970028,0.000304258,0.000001311634,0.000003168087,0.00004549683,0.000003445896,0.0004831572,0.9985036,0.000007776244,0.0004405379,0.000002301856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937446,0.001572419,0.003173627,0.00007679369,0.00002319301,0.00003082131,0.0001430035,0.00007665787,0.001158911],"genre_scores_gemma":[0.9946125,0.0005725438,0.003709364,0.00003084934,0.000005985502,0.00002314691,0.0001869876,0.00001355687,0.0008451375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000689534,"threshold_uncertainty_score":0.001913905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007036431705356835,"score_gpt":0.2357096317502788,"score_spread":0.2286732000449219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}