{"id":"W3045933555","doi":"10.1002/rth2.12412","title":"Nonacog beta pegol (N9‐GP) in hemophilia B: First report on safety and efficacy in previously untreated and minimally treated patients","year":2020,"lang":"en","type":"article","venue":"Research and Practice in Thrombosis and Haemostasis","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; McMaster Children's Hospital","funders":"Genentech; Grifols; Swedish Orphan Biovitrum; Baxalta; CSL Behring; Biogen; Novo Nordisk; Sanofi; Pfizer","keywords":"Medicine; Factor IX; Haemophilia; Dosing; Bleed; Clinical endpoint; Haemophilia B; Internal medicine; Surgery; Gastroenterology; Coagulopathy; Haemophilia A; Pediatrics; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001910328,0.0002836531,0.0007292013,0.0001644142,0.0001565299,0.0004208002,0.000316183,0.0004241301,0.001678356],"category_scores_gemma":[0.001292146,0.0001379555,0.0006957631,0.0001571006,0.0002768167,0.0003219002,0.00026914,0.000890387,0.0001758341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000285708,"about_ca_system_score_gemma":0.0003935431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001520451,"about_ca_topic_score_gemma":0.0004376059,"domain_scores_codex":[0.9993551,0.0003769566,0.00005592161,0.00007376233,0.00009397305,0.00004422996],"domain_scores_gemma":[0.9989881,0.0003220764,0.000384303,0.00006319421,0.00006540036,0.000176927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3160101,0.01391543,0.05945475,0.003214798,0.004767768,0.0007635168,0.0005096163,0.001533877,0.05372398,0.0005020673,0.004086661,0.5415176],"study_design_scores_gemma":[0.1596111,0.6742535,0.1183714,0.0004053545,0.002938901,0.003616902,0.0001641214,0.001386534,0.01819463,0.0003267673,0.02066416,0.00006678893],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793671,0.01831177,0.0004592777,0.000231554,0.00004102592,0.0002868949,0.0002644195,0.00002005817,0.0010179],"genre_scores_gemma":[0.9923049,0.005111307,0.0006815221,0.0003987519,0.00009851516,0.0002266332,0.0006107139,0.000008502599,0.0005591429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001910328,"threshold_uncertainty_score":0.01010293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1359640871986704,"score_gpt":0.4173893994332783,"score_spread":0.2814253122346079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}