{"id":"W3045933555","doi":"10.1002/rth2.12412","title":"Nonacog beta pegol (N9‐GP) in hemophilia B: First report on safety and efficacy in previously untreated and minimally treated patients","year":2020,"lang":"en","type":"article","venue":"Research and Practice in Thrombosis and Haemostasis","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; McMaster Children's Hospital","funders":"Genentech; Grifols; Swedish Orphan Biovitrum; Baxalta; CSL Behring; Biogen; Novo Nordisk; Sanofi; Pfizer","keywords":"Medicine; Factor IX; Haemophilia; Dosing; Bleed; Clinical endpoint; Haemophilia B; Internal medicine; Surgery; Gastroenterology; Coagulopathy; Haemophilia A; Pediatrics; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001626199,0.0003028525,0.0007329269,0.0005080865,0.0002249237,0.0001394203,0.00008579697,0.0002316941,0.00005443024],"category_scores_gemma":[0.003934464,0.0002390231,0.00003531965,0.001049921,0.0003877517,0.0003612356,0.0002260927,0.0008820646,0.000009955304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001507093,"about_ca_system_score_gemma":0.0001602559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00184395,"about_ca_topic_score_gemma":0.001130272,"domain_scores_codex":[0.9964381,0.0005828776,0.0006158302,0.0009077464,0.0007211125,0.0007343259],"domain_scores_gemma":[0.9954848,0.00328381,0.0001008581,0.0002815931,0.0002311413,0.0006178216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01142424,0.002419883,0.91655,0.0005113165,0.0001710791,0.003014982,0.004133743,0.000001031262,0.0002304621,0.00004388369,0.000698721,0.06080068],"study_design_scores_gemma":[0.01384832,0.00432732,0.9728133,0.0007375201,0.00008468382,0.0001643752,0.001216967,0.0002062938,0.000515806,0.00003257331,0.005781743,0.0002710892],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9443273,0.001749195,1.409041e-7,0.04883197,0.000009784917,0.001769332,0.00003185301,0.00001842323,0.003262033],"genre_scores_gemma":[0.9541381,0.04512836,0.0001692582,0.0002218211,0.00003735427,0.00005017574,0.0001072341,0.00003326448,0.0001144258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06052959,"threshold_uncertainty_score":0.9747079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1359640871986704,"score_gpt":0.4173893994332783,"score_spread":0.2814253122346079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}