{"id":"W3045949208","doi":"10.1016/j.cllc.2020.07.009","title":"Real-World Effectiveness of Nivolumab Monotherapy After Prior Systemic Therapy in Advanced Non–Small-Cell Lung Cancer in the United States","year":2020,"lang":"en","type":"article","venue":"Clinical Lung Cancer","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novartis; AstraZeneca; Bristol-Myers Squibb Canada; Bristol-Myers Squibb","keywords":"Medicine; Nivolumab; Internal medicine; Lung cancer; Oncology; Confidence interval; Chemotherapy; Retrospective cohort study; Cancer; Performance status; Clinical trial; Immunotherapy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002950334,0.0002184299,0.0003917737,0.0002920283,0.0002572163,0.0008528149,0.0003341922,0.0004559042,0.0008001991],"category_scores_gemma":[0.007298475,0.0001450231,0.0005482174,0.0003511792,0.0004017517,0.0005584238,0.0004596248,0.0004865183,0.000102119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001711465,"about_ca_system_score_gemma":0.0008259877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005886815,"about_ca_topic_score_gemma":0.008279487,"domain_scores_codex":[0.9978757,0.001336577,0.0001652017,0.0002576879,0.000254247,0.0001106597],"domain_scores_gemma":[0.9950939,0.001639902,0.002320414,0.0001765573,0.0002961003,0.0004730806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01680276,0.001754307,0.9221097,0.0003976502,0.001363889,0.0002028619,0.0002013174,0.003882724,0.00120233,0.0001245454,0.002180477,0.04977753],"study_design_scores_gemma":[0.001452226,0.01362519,0.9736993,0.000157446,0.0007788066,0.0004580611,0.0003468136,0.006231137,0.0007613004,0.0001460817,0.002307709,0.00003600039],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968088,0.002025847,0.00006517938,0.0002795011,0.00002150928,0.00002281799,0.0003446773,0.000006326859,0.0004252382],"genre_scores_gemma":[0.9990814,0.0003422,0.00006102585,0.0001286093,0.00001877179,0.00001302326,0.0003201627,0.000001456124,0.00003318212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005886815,"threshold_uncertainty_score":0.01560307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0250523809472199,"score_gpt":0.3735398882047727,"score_spread":0.3484875072575528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}