{"id":"W3045960922","doi":"10.1186/s12943-020-01237-y","title":"LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes","year":2020,"lang":"en","type":"article","venue":"Molecular Cancer","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":419,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Wuhan Science and Technology Project; Hubei University; Hubei University of Technology; National Natural Science Foundation of China","keywords":"Wnt signaling pathway; Autophagy; Cancer research; Pancreatic cancer; PVT1; Biology; Gemcitabine; MTT assay; Downregulation and upregulation; Cell culture; Cancer; Cell biology; Signal transduction; Long non-coding RNA; Apoptosis; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003318816,0.0005338452,0.0006028027,0.00006280492,0.0003046782,0.00009962662,0.0004484883,0.0003286079,0.00007461827],"category_scores_gemma":[0.0004269733,0.0004607107,0.0001787543,0.000480194,0.0003867418,0.00003559191,0.000521182,0.0004849367,0.000001955391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009871054,"about_ca_system_score_gemma":0.000341947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001076549,"about_ca_topic_score_gemma":0.000362044,"domain_scores_codex":[0.9965737,0.0002961131,0.0006120452,0.001157612,0.0006023308,0.0007581651],"domain_scores_gemma":[0.9984282,0.00007330791,0.0003963396,0.0005730714,0.0002873933,0.0002417433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003282019,0.00003692909,0.0001540642,0.000391117,0.0003802603,0.00003237824,0.0007735834,0.0006443511,0.9914877,0.0002004848,0.0002334851,0.005337488],"study_design_scores_gemma":[0.001266518,0.0003153324,0.0005190024,0.0002945763,0.0001155507,0.00001623229,0.0001730767,0.003321769,0.9884683,0.0003683844,0.004617047,0.0005242264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.933576,0.03939972,0.0214274,0.003553926,0.0001376231,0.001328013,0.0001868242,0.00005435693,0.000336111],"genre_scores_gemma":[0.993767,0.001732742,0.002273919,0.0009886527,0.0002402954,0.0004730083,0.00005625292,0.000144945,0.0003231988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06019096,"threshold_uncertainty_score":0.9997845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01643469309966235,"score_gpt":0.269680380200385,"score_spread":0.2532456871007227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}