{"id":"W3045963870","doi":"10.1021/acs.jmedchem.0c00665","title":"Peptide Inhibitors of Bacterial Protein Synthesis with Broad Spectrum and SbmA-Independent Bactericidal Activity against Clinical Pathogens","year":2020,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Argonne National Laboratory; National Center for Research Resources; National Institute of General Medical Sciences; Office of Science; National Institutes of Health; University of Illinois at Urbana-Champaign; Institute of Infection and Immunity; Office of Research Infrastructure Programs, National Institutes of Health; University of Illinois at Chicago; Joint Programming Initiative on Antimicrobial Resistance; U.S. Department of Energy","keywords":"Antimicrobial; Klebsiella pneumoniae; Escherichia coli; Chemistry; Antimicrobial peptides; Microbiology; Ribosome; Antibacterial activity; Bacteria; Staphylococcus aureus; Pseudomonas aeruginosa; Peptide; Biochemistry; Biology; Gene; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001233107,0.0002345568,0.0001941595,0.0000870207,0.00006104761,0.0001487427,0.0001473458,0.0001724368,0.0005882356],"category_scores_gemma":[0.0001162707,0.00007589687,0.0001368828,0.00006683917,0.0001487644,0.0001526904,0.0001301312,0.0003169547,0.0001691688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001184209,"about_ca_system_score_gemma":0.0001344994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001046998,"about_ca_topic_score_gemma":0.0001934637,"domain_scores_codex":[0.9999518,0.00001063297,0.000003383748,0.000006239145,0.00001513498,0.00001280056],"domain_scores_gemma":[0.9999598,0.000007162822,0.00001205296,0.000002821671,0.000007592097,0.00001055986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001737066,0.000051876,0.000270851,0.0001298906,0.00001468483,0.00008822115,0.00001022154,0.001068727,0.9894711,0.0003054049,0.00007650816,0.008338787],"study_design_scores_gemma":[0.0001216856,0.00227469,0.002405852,0.00002538122,0.00004539669,0.0006349962,0.00002144852,0.004741641,0.9815025,0.0001499598,0.008062078,0.00001436105],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849786,0.009523047,0.003433836,0.00008949661,0.00003586102,0.00004313019,0.000108347,0.00005328825,0.001734361],"genre_scores_gemma":[0.9919986,0.003157285,0.003687518,0.00006550328,0.00001261365,0.00003337129,0.000195048,0.00000744348,0.0008425451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005882356,"threshold_uncertainty_score":0.001967847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01340001928788845,"score_gpt":0.2299409776358579,"score_spread":0.2165409583479695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}