{"id":"W3045963870","doi":"10.1021/acs.jmedchem.0c00665","title":"Peptide Inhibitors of Bacterial Protein Synthesis with Broad Spectrum and SbmA-Independent Bactericidal Activity against Clinical Pathogens","year":2020,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Argonne National Laboratory; National Center for Research Resources; National Institute of General Medical Sciences; Office of Science; National Institutes of Health; University of Illinois at Urbana-Champaign; Institute of Infection and Immunity; Office of Research Infrastructure Programs, National Institutes of Health; University of Illinois at Chicago; Joint Programming Initiative on Antimicrobial Resistance; U.S. Department of Energy","keywords":"Antimicrobial; Klebsiella pneumoniae; Escherichia coli; Chemistry; Antimicrobial peptides; Microbiology; Ribosome; Antibacterial activity; Bacteria; Staphylococcus aureus; Pseudomonas aeruginosa; Peptide; Biochemistry; Biology; Gene; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000431917,0.0002170506,0.0007553538,0.00003026338,0.00006581807,0.00001386367,0.0001816159,0.0002501683,0.0003458584],"category_scores_gemma":[0.0002870707,0.0001563505,0.0001790063,0.00006853259,0.0005024729,0.0001251119,0.00008242596,0.0007587773,0.000003651709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003087215,"about_ca_system_score_gemma":0.0002267907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001521033,"about_ca_topic_score_gemma":0.000002805577,"domain_scores_codex":[0.9986216,0.0001214735,0.0006661999,0.0002210821,0.0001235022,0.0002460888],"domain_scores_gemma":[0.9986104,0.0001638464,0.0009011726,0.0001181766,0.00008845268,0.0001179314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002859943,0.0001644113,0.003018704,0.0001825693,0.0002786446,0.0001201133,0.0002077946,0.000001170449,0.9879624,0.000001025558,0.0007493151,0.004453863],"study_design_scores_gemma":[0.001738339,0.0008026968,0.005929022,0.0004636223,0.0001635138,0.0005821892,0.0008219595,0.00000143802,0.9878879,0.000003857994,0.001431538,0.0001739076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977054,0.0002245484,0.00006029013,0.001359172,0.0001832149,0.00009558599,0.00003777266,0.0000100683,0.0003239257],"genre_scores_gemma":[0.998807,0.0001242572,0.0001505323,0.00009129691,0.0006943652,0.000001531218,0.000005271699,0.00001765119,0.000108133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004279955,"threshold_uncertainty_score":0.6375787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01340001928788845,"score_gpt":0.2299409776358579,"score_spread":0.2165409583479695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}