{"id":"W3045981486","doi":"10.1161/circresaha.120.316710","title":"Atrial Myocyte NLRP3/CaMKII Nexus Forms a Substrate for Postoperative Atrial Fibrillation","year":2020,"lang":"en","type":"article","venue":"Circulation Research","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":279,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute","funders":"Canadian Institutes of Health Research; ZonMw; Deutsche Forschungsgemeinschaft; National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada; Government of Canada","keywords":"Ryanodine receptor 2; Phospholamban; Ryanodine receptor; Internal medicine; Atrial fibrillation; Connexin; Endocrinology; Calsequestrin; Patch clamp; Cardiology; Myocyte; Heart failure; Chemistry; Medicine; Calcium; Gap junction; Intracellular; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005605062,0.0001337696,0.000324866,0.0001345766,0.0003531119,0.00005383826,0.0000603335,0.000192528,0.0001131726],"category_scores_gemma":[0.001030334,0.0001180968,0.0004674493,0.0005114947,0.000116396,0.0001828529,0.00003582825,0.0003621124,0.0001384295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001294526,"about_ca_system_score_gemma":0.0004141315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001772471,"about_ca_topic_score_gemma":0.00000487734,"domain_scores_codex":[0.9982149,0.0001866349,0.0003041527,0.0004111294,0.0004448059,0.0004383477],"domain_scores_gemma":[0.9985123,0.0004326049,0.0000629722,0.0001952477,0.0005844362,0.0002124308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.08409327,0.00008468964,0.02639981,0.0008951795,0.00238268,0.0004593412,0.01041388,0.2805767,0.4278525,0.05703666,0.01198146,0.09782381],"study_design_scores_gemma":[0.04881493,0.01163844,0.294497,0.0002107432,0.0007018811,0.0004291122,0.001715622,0.5643489,0.01816444,0.01726048,0.04063809,0.001580406],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851032,0.0004816125,0.001222689,0.009653031,0.0001923975,0.001979518,0.00002595513,0.00007493817,0.001266656],"genre_scores_gemma":[0.9939796,0.00004498508,0.0001173928,0.0002504287,0.005080661,0.00001880448,0.0003099513,0.00002689586,0.0001713375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4096881,"threshold_uncertainty_score":0.481585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09328637095640954,"score_gpt":0.3846813880311808,"score_spread":0.2913950170747712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}