{"id":"W3045981486","doi":"10.1161/circresaha.120.316710","title":"Atrial Myocyte NLRP3/CaMKII Nexus Forms a Substrate for Postoperative Atrial Fibrillation","year":2020,"lang":"en","type":"article","venue":"Circulation Research","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":279,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute","funders":"Canadian Institutes of Health Research; ZonMw; Deutsche Forschungsgemeinschaft; National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada; Government of Canada","keywords":"Ryanodine receptor 2; Phospholamban; Ryanodine receptor; Internal medicine; Atrial fibrillation; Connexin; Endocrinology; Calsequestrin; Patch clamp; Cardiology; Myocyte; Heart failure; Chemistry; Medicine; Calcium; Gap junction; Intracellular; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001936305,0.0002439296,0.0002926367,0.0003339384,0.0001876832,0.0003422063,0.0001712198,0.0003677596,0.002041033],"category_scores_gemma":[0.0009387339,0.000109588,0.0001486354,0.0001856448,0.0003761745,0.0002532636,0.0003382523,0.0003125997,0.0003384005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009616649,"about_ca_system_score_gemma":0.0001072646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008830115,"about_ca_topic_score_gemma":0.0001142872,"domain_scores_codex":[0.9998647,0.00002204267,0.00002571619,0.00003730161,0.00002681098,0.00002333127],"domain_scores_gemma":[0.9994295,0.000129718,0.0002977719,0.00003078816,0.0000333388,0.00007887911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00292075,0.000109617,0.5723514,0.0004733797,0.0001193278,0.01597782,0.0002882879,0.0002725109,0.3833084,0.0004463417,0.0006305863,0.02310166],"study_design_scores_gemma":[0.00004657085,0.0004514865,0.9442951,0.00006786521,0.00007881848,0.03538807,0.0003004064,0.0008790338,0.0166365,0.0004277314,0.001415511,0.00001275867],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967217,0.001803161,0.0006774404,0.0001487051,0.00001467983,0.00001340007,0.00008432405,0.00001654271,0.0005201144],"genre_scores_gemma":[0.9989838,0.0004160485,0.0002904424,0.0000458097,0.00002966587,0.000008815322,0.0001193251,0.000002416115,0.0001035682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002041033,"threshold_uncertainty_score":0.00682795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09328637095640954,"score_gpt":0.3846813880311808,"score_spread":0.2913950170747712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}