{"id":"W3046025409","doi":"10.1182/blood.2019002973","title":"Assembly of alternative prothrombinase by extracellular histones initiates and disseminates intravascular coagulation","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Academy of Medical Sciences; University of Liverpool; University of Manchester; British Heart Foundation; National Institute for Health and Care Research","keywords":"Prothrombinase; Thrombin; Disseminated intravascular coagulation; Coagulation; Histone; Chemistry; Thromboplastin; Cell biology; Immunology; Biochemistry; Medicine; Internal medicine; Biology; Platelet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000137269,0.0001827734,0.0001480794,0.0001227688,0.00006508729,0.0002174098,0.00008782626,0.0001737592,0.0006380712],"category_scores_gemma":[0.0001880307,0.00007668928,0.0001556,0.00008644193,0.0001282532,0.0001561516,0.0001975539,0.0001875095,0.0001595137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001181657,"about_ca_system_score_gemma":0.00007703848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000150538,"about_ca_topic_score_gemma":0.0001738981,"domain_scores_codex":[0.9998888,0.00002365414,0.00001221432,0.0000269749,0.00002393221,0.00002443236],"domain_scores_gemma":[0.9998988,0.00001040408,0.00004180283,0.00001374625,0.00001209693,0.00002317748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002915434,0.00002006807,0.004038177,0.00004917257,0.00001429316,0.0002459276,0.00005106019,0.00002896899,0.9905503,0.0001566995,0.00004973555,0.004504085],"study_design_scores_gemma":[0.00009486928,0.002146095,0.115834,0.00003146512,0.00007373842,0.003463284,0.0001863302,0.001261433,0.8696734,0.0002468052,0.006974879,0.00001373038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959274,0.001901056,0.001564561,0.00002814279,0.00001565343,0.00001423973,0.00005416705,0.0000187747,0.0004760034],"genre_scores_gemma":[0.9983197,0.0004474853,0.0007124343,0.00003293192,0.00001398828,0.000006641099,0.0001145859,0.000002653154,0.0003495636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006380712,"threshold_uncertainty_score":0.002134562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02266700603234374,"score_gpt":0.2592546481031574,"score_spread":0.2365876420708137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}