{"id":"W3046044117","doi":"10.1002/hbm.25098","title":"What we learn about bipolar disorder from large‐scale neuroimaging: Findings and future directions from the <scp>ENIGMA</scp> Bipolar Disorder Working Group","year":2020,"lang":"en","type":"review","venue":"Human Brain Mapping","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital; University of British Columbia; Dalhousie University; University of Toronto; Sunnybrook Health Science Centre; Ontario Brain Institute; Holland Bloorview Kids Rehabilitation Hospital","funders":"FP7 People: Marie-Curie Actions; National Center for Advancing Translational Sciences; National Institute of Biomedical Imaging and Bioengineering; National Institute on Aging; National Institute of Mental Health; Helse Sør-Øst RHF; Japan Society for the Promotion of Science; National Health and Medical Research Council; Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Fok Ying Tung Education Foundation; National Center of Neurology and Psychiatry; Centro de Investigación Biomédica en Red de Salud Mental; Hersenstichting; Universidad de Antioquia; Brain and Behavior Research Foundation; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Centre of Excellence in Cognition and its Disorders, Australian Research Council; Ministero della Salute; South London and Maudsley NHS Foundation Trust; Fondation pour la Recherche Médicale; FP7 Health; Macquarie University; Generalitat de Catalunya; Natural Sciences and Engineering Research Council of Canada; Ministry of Education, Culture, Sports, Science and Technology; Bundesministerium für Bildung und Forschung; Irish Research Council; Vetenskapsrådet; Instituto de Salud Carlos III; National Natural Science Foundation of China; University of New South Wales; Australian Government; Norges Forskningsråd; Stiftelsen för Strategisk Forskning; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Health Research Board; National Institute for Health and Care Research; National Research Foundation; University of Cape Town; Nova Scotia Health Research Foundation; Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS); Japan Agency for Medical Research and Development; Centres de Recerca de Catalunya; UK Research and Innovation; Killam Trusts; European Commission; Fundação de Amparo à Pesquisa do Estado de São Paulo; AstraZeneca; ZonMw; National Institute of General Medical Sciences; National Alliance for Research on Schizophrenia and Depression; Agence Nationale de la Recherche; Pittsburgh Foundation; European Regional Development Fund; King's College London; Wellcome Trust; Fondation de l'Avenir pour la Recherche Médicale Appliquée; Ministerstvo Zdravotnictví Ceské Republiky; John S. Dunn Foundation; William K. Warren Foundation; Ministerio de Ciencia, Innovación y Universidades","keywords":"Neuroimaging; Bipolar disorder; Psychology; Clinical psychology; White matter; Neuroscience; Psychiatry; Magnetic resonance imaging; Medicine; Cognition","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","research_integrity"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0004231704,0.001335346,0.002531044,0.0003884588,0.00200748,0.0009424295,0.0006142826,0.0006771188,0.0002083063],"category_scores_gemma":[0.0001797759,0.001031803,0.001065399,0.001109325,0.0002677516,0.000429696,0.0005945936,0.002630519,0.0001405467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001693934,"about_ca_system_score_gemma":0.000134455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006288688,"about_ca_topic_score_gemma":0.001648743,"domain_scores_codex":[0.9946368,0.0007024938,0.001069188,0.001851118,0.0006719672,0.001068431],"domain_scores_gemma":[0.9962732,0.001520957,0.0004972835,0.001209042,0.00005882169,0.0004406961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000003844854,0.0003242026,0.02588895,0.001748705,0.001398869,0.00005017749,0.01220431,1.520764e-7,0.00002391649,0.0001704899,0.001999475,0.9561869],"study_design_scores_gemma":[0.001308828,0.00007877771,0.03362697,0.0102974,0.002281276,0.00004806346,0.005241067,0.00003372885,1.376079e-7,0.0002781578,0.9463958,0.0004097923],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001150587,0.9890441,0.0003102366,0.00536147,0.00121572,0.002002229,0.0003143044,0.0004331148,0.0001682302],"genre_scores_gemma":[0.0001260212,0.9916407,0.0002666292,0.001035524,0.002888482,0.0002579787,0.002522741,0.0003624492,0.0008994209],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9557771,"threshold_uncertainty_score":0.9999398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03118730904310637,"score_gpt":0.2822962925306015,"score_spread":0.2511089834874951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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