{"id":"W3046049502","doi":"10.1038/s41598-020-69267-6","title":"β1 integrin, ILK and mTOR regulate collagen synthesis in mechanically loaded tendon cells","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Tendon Structure and Treatment","field":"Medicine","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Integrin; Tendon; PI3K/AKT/mTOR pathway; Cell biology; Chemistry; Medicine; Biology; Anatomy; Signal transduction; Biochemistry; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007868579,0.0001965901,0.0001550771,0.0002637387,0.0001997156,0.0004164705,0.00009129285,0.0001930086,0.001159963],"category_scores_gemma":[0.00009900684,0.0001064042,0.0001931307,0.000113792,0.0001730296,0.0001742797,0.000152044,0.0003053577,0.0002781081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000205644,"about_ca_system_score_gemma":0.000158715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004552903,"about_ca_topic_score_gemma":0.0008788384,"domain_scores_codex":[0.9999076,0.00001765211,0.000007837917,0.00001787914,0.00001615321,0.00003278703],"domain_scores_gemma":[0.9999572,0.000005796075,0.00001534531,0.000002356307,0.000006291448,0.00001297151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004236831,0.00008303552,0.001079821,0.00008290836,0.00001013114,0.0001303159,0.00004205143,0.0001134338,0.9941844,0.0002987516,0.0001813232,0.003370106],"study_design_scores_gemma":[0.0001710508,0.0008110845,0.1402904,0.00004486277,0.00009303613,0.0009811971,0.0005079523,0.004471692,0.843502,0.0007361319,0.008367908,0.00002273183],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884573,0.006230718,0.00113364,0.0002618667,0.00007444762,0.00002184558,0.0002056778,0.00004316454,0.003571361],"genre_scores_gemma":[0.9960235,0.001507121,0.0005829458,0.00008420554,0.0000210232,0.00002665246,0.0001307791,0.000006565002,0.001617231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001159963,"threshold_uncertainty_score":0.003880501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01648513470302132,"score_gpt":0.235218217282394,"score_spread":0.2187330825793727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}