{"id":"W3046139269","doi":"10.1128/mbio.00986-20","title":"A Cytoplasmic Heme Sensor Illuminates the Impacts of Mitochondrial and Vacuolar Functions and Oxidative Stress on Heme-Iron Homeostasis in Cryptococcus neoformans","year":2020,"lang":"en","type":"article","venue":"mBio","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; National Research Foundation of Korea","keywords":"Heme; Cryptococcus neoformans; Oxidative stress; Biology; Mitochondrion; Artemisinin; Biochemistry; Antifungal drug; Hemin; Oxidative phosphorylation; Cell biology; Chemistry; Plasmodium falciparum; Microbiology; Malaria; Antifungal; Immunology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004604899,0.0001185904,0.0002295335,0.00006806037,0.0001212742,0.00001463055,0.000023805,0.0000490419,0.00002804563],"category_scores_gemma":[0.0001402393,0.0000766563,0.00003821215,0.0001870581,0.0001374171,0.00005561629,0.00004648838,0.0001740764,0.000006811119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002428096,"about_ca_system_score_gemma":0.00001826438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002017848,"about_ca_topic_score_gemma":0.0002052399,"domain_scores_codex":[0.9994023,0.0000307796,0.0001589902,0.0001631585,0.00009353066,0.0001512023],"domain_scores_gemma":[0.9995956,0.0001345763,0.00004945655,0.0001027986,0.00004409625,0.0000734841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003451262,0.001095184,0.5418207,0.001076565,0.0007458774,0.0001029801,0.04261955,0.00007639542,0.3849978,0.0005951271,0.01037511,0.01304343],"study_design_scores_gemma":[0.009835397,0.008773938,0.7483619,0.0006370877,0.0005111905,0.00007397922,0.03903745,0.00119142,0.1798149,0.00009029434,0.01108944,0.0005829312],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954247,0.0004378995,0.00001420447,0.002995867,0.00008398227,0.000422992,0.0001005685,0.00001740155,0.0005024209],"genre_scores_gemma":[0.9991788,0.0003088658,0.00008302238,0.0002189123,0.00008698199,0.00002388129,0.00001066103,0.000008617026,0.00008026778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2065413,"threshold_uncertainty_score":0.3125953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01640830181455962,"score_gpt":0.2530670989077252,"score_spread":0.2366587970931656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}