{"id":"W3046139269","doi":"10.1128/mbio.00986-20","title":"A Cytoplasmic Heme Sensor Illuminates the Impacts of Mitochondrial and Vacuolar Functions and Oxidative Stress on Heme-Iron Homeostasis in Cryptococcus neoformans","year":2020,"lang":"en","type":"article","venue":"mBio","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; National Research Foundation of Korea","keywords":"Heme; Cryptococcus neoformans; Oxidative stress; Biology; Mitochondrion; Artemisinin; Biochemistry; Antifungal drug; Hemin; Oxidative phosphorylation; Cell biology; Chemistry; Plasmodium falciparum; Microbiology; Malaria; Antifungal; Immunology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001358879,0.0001773191,0.0001429842,0.000157834,0.0001664714,0.0001610146,0.0001700781,0.0002932148,0.0004603832],"category_scores_gemma":[0.00007481348,0.00007046649,0.0001023309,0.0001241537,0.0002119019,0.0001627803,0.0001966167,0.0003293913,0.00008565453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003621631,"about_ca_system_score_gemma":0.0002432152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002028123,"about_ca_topic_score_gemma":0.001776906,"domain_scores_codex":[0.9999201,0.00001036412,0.000004091898,0.00001638698,0.00002581529,0.00002318848],"domain_scores_gemma":[0.9999509,0.000009588588,0.00001155401,0.000004624968,0.00001173929,0.00001161452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003760346,0.000006906477,0.000162978,0.00001235453,6.19094e-7,0.00002660771,0.000008372913,0.00002829507,0.9990069,0.00007797996,0.00001472422,0.0006166573],"study_design_scores_gemma":[0.000003053966,0.00007981554,0.003270479,0.000003756902,0.000003190682,0.0001545753,0.00004321782,0.001274978,0.9945681,0.00005432063,0.0005413613,0.000003104735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915193,0.0006059835,0.006157046,0.000199831,0.00001288032,0.00001688439,0.000203688,0.00007417903,0.001210264],"genre_scores_gemma":[0.9937769,0.0002957541,0.004660588,0.00008417761,0.0000027055,0.00001150358,0.0001011543,0.000008625238,0.001058555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002028123,"threshold_uncertainty_score":0.004032612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01640830181455962,"score_gpt":0.2530670989077252,"score_spread":0.2366587970931656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}