{"id":"W3046182450","doi":"10.1002/hep4.1559","title":"Targeted Inhibition of Purine Metabolism Is Effective in Suppressing Hepatocellular Carcinoma Progression","year":2020,"lang":"en","type":"article","venue":"Hepatology Communications","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Cancer Science Institute of Singapore, National University of Singapore; Biomedical Research Council; National Medical Research Council; Medical Research Council; Agency for Science, Technology and Research","keywords":"Cancer research; Biology; Carcinogenesis; Purine metabolism; Kinome; Gene knockdown; PI3K/AKT/mTOR pathway; Cancer; Kinase; Signal transduction; Biochemistry; Enzyme; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001575608,0.0002617243,0.000326107,0.0002068151,0.0001075415,0.0002860089,0.0001498571,0.0001615225,0.0006869353],"category_scores_gemma":[0.0001145135,0.0001131645,0.0001729668,0.000162116,0.0001820752,0.0001349215,0.0001277196,0.0004034173,0.0001302685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000201958,"about_ca_system_score_gemma":0.0001970871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003626596,"about_ca_topic_score_gemma":0.0009510249,"domain_scores_codex":[0.9999075,0.00001761074,0.000008847522,0.00002070498,0.00002040755,0.00002496268],"domain_scores_gemma":[0.9999279,0.00001695421,0.00001915293,0.00001206589,0.000005272589,0.00001869586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003361946,0.0001111512,0.0003668837,0.000048082,0.00001661571,0.00003254412,0.00001112113,0.0002134176,0.9908568,0.0000900478,0.00006838472,0.007848656],"study_design_scores_gemma":[0.00005494585,0.002282069,0.009670134,0.000006327784,0.00004497029,0.0002900557,0.00002443976,0.001646501,0.9828358,0.00006795721,0.003069652,0.000007066408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949265,0.001978481,0.001789506,0.00006343501,0.00002017429,0.00003104215,0.0001719687,0.0001065549,0.0009124608],"genre_scores_gemma":[0.9975123,0.0009890164,0.0006721249,0.00002264096,0.000005251306,0.0000208382,0.0002164341,0.00000776808,0.0005536314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006869353,"threshold_uncertainty_score":0.002298057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02426975263307178,"score_gpt":0.3015273371020254,"score_spread":0.2772575844689536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}