{"id":"W3046197426","doi":"10.2147/jir.s258991","title":"<p>Protective Effects of Leukadherin1 in a Rat Model of Targeted Experimental Autoimmune Encephalomyelitis (EAE): Possible Role of P47phox and MDA Downregulation</p>","year":2020,"lang":"en","type":"article","venue":"Journal of Inflammation Research","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Tehran University of Medical Sciences and Health Services","keywords":"Experimental autoimmune encephalomyelitis; Microglia; Multiple sclerosis; Integrin alpha M; Encephalomyelitis; Medicine; Spinal cord; Downregulation and upregulation; Pharmacology; Intraperitoneal injection; Immunology; Astrogliosis; Pathology; Immune system; Central nervous system; Inflammation; Chemistry; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001550161,0.0004837186,0.0004872766,0.0002791683,0.0002025027,0.0002766135,0.0002266465,0.0003715467,0.001865138],"category_scores_gemma":[0.00008293367,0.0001369354,0.0002656137,0.000164064,0.0003661577,0.0003514862,0.0001227757,0.001050024,0.0004667793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002534491,"about_ca_system_score_gemma":0.0002463658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005939096,"about_ca_topic_score_gemma":0.000773239,"domain_scores_codex":[0.9998786,0.00001191473,0.00001069266,0.00002433322,0.00002715051,0.00004713583],"domain_scores_gemma":[0.9998704,0.000009352986,0.00004326151,0.00001025624,0.00001672295,0.00004995321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008139264,0.0002411544,0.0001960096,0.00007931259,0.000008980237,0.0001191201,0.00001754788,0.00005045811,0.9952555,0.0001085884,0.000114657,0.002994706],"study_design_scores_gemma":[0.00005990089,0.002159845,0.002769017,0.00001211035,0.00003500325,0.0001957304,0.0000389819,0.0003926092,0.9928837,0.00005838904,0.001390015,0.000004728225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995221,0.0009651536,0.00173258,0.0002933659,0.00006463291,0.00003909513,0.0003497454,0.0001698557,0.001164614],"genre_scores_gemma":[0.9894966,0.001179497,0.002648526,0.0001225216,0.00003222685,0.00009336914,0.0005296718,0.00003439408,0.005863182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001865138,"threshold_uncertainty_score":0.006239533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03975202733754121,"score_gpt":0.3296708774278697,"score_spread":0.2899188500903285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}