{"id":"W3046274973","doi":"10.3389/fgene.2020.00813","title":"Transcriptomic Changes Resulting From STK32B Overexpression Identify Pathways Potentially Relevant to Essential Tremor","year":2020,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Neurological Institute and Hospital; McGill University","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Biology; Transcriptome; Gene; Genome-wide association study; Genetics; Candidate gene; Gene expression; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008846408,0.0002871885,0.0002600924,0.00008386915,0.00008673038,0.00006032785,0.0004405084,0.0001974223,0.00001899689],"category_scores_gemma":[0.00007038827,0.0003176265,0.00009514201,0.0001859855,0.00004880349,0.000004014472,0.0002424526,0.0001556317,0.00001295423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002220344,"about_ca_system_score_gemma":0.00007643987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002423084,"about_ca_topic_score_gemma":0.00009819485,"domain_scores_codex":[0.9980248,0.00008802592,0.000377618,0.0007928508,0.0002827989,0.0004339298],"domain_scores_gemma":[0.9992739,0.000005520011,0.00009481763,0.0003306601,0.00004585123,0.0002492674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002948212,0.00005029106,0.002746408,0.00002096078,0.00003703258,0.00001203001,0.0007333019,0.0008020187,0.9682422,8.731917e-7,0.01729868,0.00976136],"study_design_scores_gemma":[0.001896182,0.0004312544,0.04415486,0.0000631915,0.00003748645,0.000001852662,0.0007372453,0.001401853,0.9045419,0.0001116188,0.04597618,0.000646439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753383,0.001445042,0.02031346,0.001213085,0.0009014509,0.000418597,0.0001740324,0.00002309023,0.0001728862],"genre_scores_gemma":[0.9606373,0.001555022,0.03514856,0.001997086,0.0002168019,0.00002375024,0.0002857769,0.0000679294,0.00006779585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06370039,"threshold_uncertainty_score":0.9999276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01448280789451554,"score_gpt":0.2302683967815586,"score_spread":0.2157855888870431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}