{"id":"W3046274973","doi":"10.3389/fgene.2020.00813","title":"Transcriptomic Changes Resulting From STK32B Overexpression Identify Pathways Potentially Relevant to Essential Tremor","year":2020,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Neurological Institute and Hospital; McGill University","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Biology; Transcriptome; Gene; Genome-wide association study; Genetics; Candidate gene; Gene expression; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009467733,0.0003357979,0.0002213073,0.0002786304,0.000222208,0.000287395,0.00009507477,0.0002661975,0.001316181],"category_scores_gemma":[0.0001508574,0.000101908,0.0003590558,0.00033071,0.0001560569,0.0001597789,0.0002273538,0.0002944519,0.0002921272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002701634,"about_ca_system_score_gemma":0.0001809023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007552134,"about_ca_topic_score_gemma":0.001551693,"domain_scores_codex":[0.9999216,0.000005324709,0.000006537634,0.0000286928,0.00002056276,0.00001726513],"domain_scores_gemma":[0.9999022,0.00002025738,0.00004100472,0.000006075801,0.00001134738,0.00001902165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002585599,0.00000811695,0.003813556,0.00008574995,0.00001677004,0.0001833723,0.0000235092,0.0001846138,0.9941347,0.00006285289,0.0001096296,0.001118436],"study_design_scores_gemma":[0.000089015,0.0004370092,0.4299652,0.00009423563,0.0002113899,0.001910689,0.0003437281,0.005728354,0.5517904,0.0008037775,0.00859795,0.00002822772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925072,0.0014838,0.001650814,0.0001337387,0.00002375696,0.0000130421,0.003559752,0.00007187219,0.0005561152],"genre_scores_gemma":[0.9915154,0.0009237766,0.001874962,0.0001023785,0.000006321618,0.0000354962,0.004159233,0.00002854946,0.001353864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001316181,"threshold_uncertainty_score":0.004403114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01448280789451554,"score_gpt":0.2302683967815586,"score_spread":0.2157855888870431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}