{"id":"W3046293265","doi":"10.1016/j.omto.2020.07.008","title":"Molecular Rules Underpinning Enhanced Affinity Binding of Human T Cell Receptors Engineered for Immunotherapy","year":2020,"lang":"en","type":"article","venue":"Molecular Therapy — Oncolytics","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Biotechnology and Biological Sciences Research Council; University of Bristol; Engineering and Physical Sciences Research Council; University of Bath; Canolfan Ymchwil Canser Cymru; Cancer Research UK; Wellcome Trust","keywords":"Underpinning; Receptor; Immunotherapy; Cell biology; Chemistry; Cell; Computational biology; Biology; Biochemistry; Immunology; Immune system; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004514104,0.0004479377,0.0008657421,0.000247189,0.000136207,0.00005357306,0.0004321567,0.0002891926,0.0006479633],"category_scores_gemma":[0.0001116045,0.0004551132,0.0005762808,0.0006126274,0.000154876,0.00006542489,0.00006410704,0.0004874933,0.00002207814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002356053,"about_ca_system_score_gemma":0.0002893564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001625497,"about_ca_topic_score_gemma":7.546969e-7,"domain_scores_codex":[0.997183,0.0001432866,0.000697623,0.0005768108,0.0007484647,0.000650788],"domain_scores_gemma":[0.9982409,0.0001765739,0.0002621999,0.0006634688,0.0003362734,0.0003205232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001306422,0.0003437524,0.0000534363,0.0002390089,0.0004448477,0.00003932433,0.001428702,0.0003438866,0.9823642,0.000362581,0.0001350538,0.01293882],"study_design_scores_gemma":[0.007895226,0.003128198,0.00003081259,0.0001061677,0.00006332211,0.000004249366,0.0003018549,0.0009447269,0.9765014,0.0002203093,0.01039944,0.0004042872],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9462325,0.001647514,0.04652934,0.001106372,0.0001392218,0.002042761,0.00003070189,0.0001600033,0.002111613],"genre_scores_gemma":[0.9878025,0.0006478794,0.008887798,0.001398236,0.0001583696,0.0001205458,0.0001429632,0.000249864,0.0005918682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04157,"threshold_uncertainty_score":0.9997901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04400329613346489,"score_gpt":0.3283295559010888,"score_spread":0.2843262597676239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}