{"id":"W3046293265","doi":"10.1016/j.omto.2020.07.008","title":"Molecular Rules Underpinning Enhanced Affinity Binding of Human T Cell Receptors Engineered for Immunotherapy","year":2020,"lang":"en","type":"article","venue":"Molecular Therapy — Oncolytics","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Biotechnology and Biological Sciences Research Council; University of Bristol; Engineering and Physical Sciences Research Council; University of Bath; Canolfan Ymchwil Canser Cymru; Cancer Research UK; Wellcome Trust","keywords":"Underpinning; Receptor; Immunotherapy; Cell biology; Chemistry; Cell; Computational biology; Biology; Biochemistry; Immunology; Immune system; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001599407,0.0002301777,0.0002202722,0.0001288748,0.0002742823,0.0005037613,0.0003181581,0.000365613,0.001361275],"category_scores_gemma":[0.0003499967,0.0002432022,0.0001568288,0.00008063824,0.000451696,0.0004693692,0.0002510702,0.0005756299,0.0002441034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004105855,"about_ca_system_score_gemma":0.000327514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006865675,"about_ca_topic_score_gemma":0.001115603,"domain_scores_codex":[0.9998755,0.0000193724,0.000007365742,0.00002220279,0.00004167321,0.00003373397],"domain_scores_gemma":[0.9999398,0.00002386428,0.00001521024,0.000004136468,0.000007437205,0.000009588755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002058326,0.0001036785,0.001531812,0.0001129679,0.00002700477,0.0004948931,0.00008963539,0.05008826,0.9193168,0.02381958,0.0003497557,0.003859761],"study_design_scores_gemma":[0.0001702306,0.0003411407,0.005560568,0.00002752038,0.00005721905,0.0008326781,0.0002974895,0.3613791,0.6087361,0.01636199,0.006171172,0.0000648132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983196,0.0004341064,0.0124462,0.0001102971,0.00001616933,0.00002541077,0.00005357679,0.00006626788,0.003651917],"genre_scores_gemma":[0.9969016,0.0002683355,0.002324812,0.00003352981,0.000002600822,0.00001584567,0.00004298276,0.00001251112,0.0003977939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001361275,"threshold_uncertainty_score":0.004553914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04400329613346489,"score_gpt":0.3283295559010888,"score_spread":0.2843262597676239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}