{"id":"W3046339125","doi":"10.3389/fcell.2020.00701","title":"Interactions With Histone H3 & Tools to Study Them","year":2020,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Garron Family Cancer Centre; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Histone code; Chromatin; Histone; Cell biology; Biology; Histone H1; Histone-modifying enzymes; Histone H3; Chromatin remodeling; Histone methyltransferase; Histone H2A; Computational biology; Nucleosome; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008471384,0.0003425541,0.0007451247,0.00008919171,0.00006905746,0.00002582699,0.0002414205,0.0001940587,0.00002437973],"category_scores_gemma":[0.00001683161,0.0002715334,0.00007083129,0.0001443475,0.00005934985,0.000002421692,0.0003206627,0.0001988119,0.0000395924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001018978,"about_ca_system_score_gemma":0.0001910406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009609726,"about_ca_topic_score_gemma":0.00007752793,"domain_scores_codex":[0.9986535,0.00008584682,0.0003732779,0.0006021459,0.00004481495,0.000240418],"domain_scores_gemma":[0.9995562,0.00001494066,0.0001212979,0.000177662,0.00001723715,0.0001126165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007345694,0.0002373707,0.002073751,0.0005206622,0.0003215421,0.00002070869,0.0004702415,8.89744e-7,0.0003824802,0.000005466256,0.006422852,0.9894706],"study_design_scores_gemma":[0.0003141902,0.0002447542,0.00004945741,0.0001243653,0.00006884929,0.00006370565,0.0004760557,8.823546e-7,0.00004710897,0.00001426107,0.9982201,0.0003762458],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0225981,0.9696303,0.002137747,0.00003153212,0.0006885598,0.001315183,0.0001361541,0.00001499372,0.00344746],"genre_scores_gemma":[0.002080414,0.9525328,0.04294631,0.0001398418,0.0000776178,0.0001963235,0.0009724716,0.0000479533,0.001006231],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9917973,"threshold_uncertainty_score":0.9999737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02541825911150389,"score_gpt":0.2828022221637228,"score_spread":0.2573839630522189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}