{"id":"W3046343760","doi":"10.1021/acs.molpharmaceut.0c00383","title":"Engineered Nanoparticle Applications for Recombinant Influenza Vaccines","year":2020,"lang":"en","type":"review","venue":"Molecular Pharmaceutics","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre","funders":"National Institute of Allergy and Infectious Diseases; Office of the Director; National Institutes of Health","keywords":"Immunogenicity; Virology; Antigen; Recombinant DNA; Virus; Pandemic; Nanomedicine; Antigenic drift; Virus-like particle; Biology; Influenza A virus; Immunology; Medicine; Coronavirus disease 2019 (COVID-19); Nanoparticle; Nanotechnology; Infectious disease (medical specialty); Gene; Materials science; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002437405,0.0005122517,0.001650367,0.0001975074,0.0001406265,0.00004287273,0.0003083549,0.0002155636,0.00002983387],"category_scores_gemma":[0.0003875454,0.0004339601,0.0006870161,0.0006758526,0.00005838624,0.0000378097,0.0002168575,0.0005888904,0.0002480008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002223972,"about_ca_system_score_gemma":0.0004661487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001370645,"about_ca_topic_score_gemma":1.789937e-7,"domain_scores_codex":[0.9976625,0.00009148207,0.0007328052,0.0005393066,0.0003659067,0.0006079293],"domain_scores_gemma":[0.9983556,0.0002056071,0.0001881797,0.0005537824,0.000307678,0.0003890971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006171363,0.0001717956,0.000002641939,0.03511579,0.001292579,0.00009720814,0.00004086933,0.000006326801,0.001078253,0.0004390755,0.001733186,0.9599606],"study_design_scores_gemma":[0.0014359,0.0001328196,3.226798e-7,0.0013393,0.003130738,0.00004525909,0.000006305167,0.0002749827,0.002840692,0.00004103147,0.9903819,0.000370756],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00000484856,0.9906054,0.002067144,0.000263113,0.0001425842,0.006381189,0.0001336583,0.0001786881,0.0002233576],"genre_scores_gemma":[0.000007725456,0.9918215,0.002168054,0.001310767,0.0002320752,0.003957183,0.0001143289,0.0001679139,0.000220463],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9886487,"threshold_uncertainty_score":0.9998112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2369184314394203,"score_gpt":0.502895530136187,"score_spread":0.2659770986967667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}