{"id":"W3046378512","doi":"10.1016/j.cmet.2020.07.004","title":"Memory CD8+ T Cells Balance Pro- and Anti-inflammatory Activity by Reprogramming Cellular Acetate Handling at Sites of Infection","year":2020,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":68,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Novartis Foundation","keywords":"Reprogramming; Balance (ability); Cellular metabolism; Inflammation; Cell biology; Biology; Immunology; Metabolism; Cell; Biochemistry; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001504005,0.0003296413,0.0003013435,0.0002679699,0.0002049666,0.00118626,0.0002690014,0.0003857619,0.003225484],"category_scores_gemma":[0.0001756709,0.0001438339,0.0001927454,0.0001645381,0.0002476231,0.0007333076,0.0004369208,0.0006306517,0.001005855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001810846,"about_ca_system_score_gemma":0.0001648188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001227807,"about_ca_topic_score_gemma":0.000296626,"domain_scores_codex":[0.999827,0.00003274198,0.00001108486,0.00004139934,0.00002153738,0.00006624972],"domain_scores_gemma":[0.9999089,0.000008838189,0.00002101336,0.00001273287,0.00001786029,0.00003062983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005183285,0.00004080886,0.001859694,0.00005229567,0.000005955327,0.00006991858,0.000068237,0.0001024559,0.9862537,0.0004378785,0.00009697619,0.01049354],"study_design_scores_gemma":[0.00008366569,0.001201742,0.02239761,0.00007334736,0.00006006733,0.000551754,0.0009065794,0.002187747,0.958442,0.001668929,0.01239847,0.00002810972],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874824,0.002264303,0.005139732,0.0003132059,0.0001218536,0.00002580353,0.0002273522,0.0001655123,0.004259845],"genre_scores_gemma":[0.9934674,0.0006354498,0.002363191,0.0000937541,0.00004235948,0.00002017968,0.0001282139,0.00003773006,0.003211666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003225484,"threshold_uncertainty_score":0.01079029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01131759801440236,"score_gpt":0.2086459281595767,"score_spread":0.1973283301451743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}