{"id":"W3046413753","doi":"10.3390/cancers12082121","title":"Histone Demethylase KDM5B as a Therapeutic Target for Cancer Therapy","year":2020,"lang":"en","type":"review","venue":"Cancers","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Demethylase; Cancer research; Computational biology; Medicine; Chemistry; Biology; Histone; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001462535,0.0004135772,0.0008046957,0.00005417879,0.00009077176,0.00002471678,0.0003055127,0.0004111856,0.0001056699],"category_scores_gemma":[0.00005148625,0.0003582325,0.0005398798,0.0001492555,0.00007137132,0.000001973491,0.00004358993,0.0001612972,0.00001429849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004270035,"about_ca_system_score_gemma":0.002434227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001017529,"about_ca_topic_score_gemma":0.00003049554,"domain_scores_codex":[0.9984444,0.0001016231,0.0003680288,0.000639116,0.0001330602,0.0003137116],"domain_scores_gemma":[0.9990398,0.00003677506,0.0003005128,0.0003763586,0.00009802278,0.0001484735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000484389,0.000007094621,0.000001289171,0.001162337,0.0003685172,0.00000148562,0.00002436786,0.00004636285,0.001839136,0.00002974985,0.00130837,0.9951628],"study_design_scores_gemma":[0.0003654143,0.0004184463,3.419012e-7,0.0002915798,0.0002053089,0.000001134482,0.00000585943,0.00001673936,0.004999614,0.0001543239,0.9931196,0.0004216666],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004476968,0.9955971,0.001710964,0.00007394124,0.0006772149,0.001152555,0.0002911856,0.00001756667,0.0004347462],"genre_scores_gemma":[0.00005200982,0.9942926,0.0005500332,0.0003904668,0.001099456,0.001184671,0.0005722747,0.000124081,0.001734371],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9947412,"threshold_uncertainty_score":0.999887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05853191120958967,"score_gpt":0.3935955386021718,"score_spread":0.3350636273925821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}