{"id":"W3046413753","doi":"10.3390/cancers12082121","title":"Histone Demethylase KDM5B as a Therapeutic Target for Cancer Therapy","year":2020,"lang":"en","type":"review","venue":"Cancers","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Demethylase; Cancer research; Computational biology; Medicine; Chemistry; Biology; Histone; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005057423,0.0006597353,0.000886447,0.001607517,0.0002154589,0.0006865207,0.0007634127,0.0009041224,0.003996632],"category_scores_gemma":[0.000474595,0.0002344579,0.0004255816,0.00121694,0.000344165,0.0009826991,0.0005739051,0.001929182,0.002010261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006283862,"about_ca_system_score_gemma":0.0006813668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006580891,"about_ca_topic_score_gemma":0.001654964,"domain_scores_codex":[0.9998918,0.00002023705,0.00001341843,0.0000177965,0.00004102239,0.00001574737],"domain_scores_gemma":[0.9998285,0.00007246107,0.0000225753,0.000005908279,0.00004856638,0.00002204948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001094472,0.00008081581,0.0001504909,0.0131215,0.0001080937,0.0002673847,0.00004422458,0.0005380535,0.003686146,0.005068679,0.04951405,0.9273112],"study_design_scores_gemma":[0.00001713552,0.0000714902,0.0003213611,0.001127868,0.00006726131,0.0007612099,0.00002129833,0.00009657516,0.0006731326,0.001196651,0.9956358,0.00001030606],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001432135,0.9979115,0.0001598684,0.0003284688,0.0002660505,0.000005235407,0.00002084324,0.000009250217,0.001155514],"genre_scores_gemma":[0.001030398,0.997244,0.000241971,0.0002594814,0.0001670052,0.00000807623,0.00005044945,0.000002255119,0.0009963881],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003996632,"threshold_uncertainty_score":0.0133701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05853191120958967,"score_gpt":0.3935955386021718,"score_spread":0.3350636273925821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}