{"id":"W3046443211","doi":"10.1111/cts.12802","title":"A Phase I Study of Dinaciclib in Combination With MK‐2206 in Patients With Advanced Pancreatic Cancer","year":2020,"lang":"en","type":"article","venue":"Clinical and Translational Science","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Center for Advancing Translational Sciences; National Center for Research Resources; National Institute of General Medical Sciences; National Cancer Institute","keywords":"Medicine; Pancreatic cancer; Neutropenia; Leukopenia; Internal medicine; Gastroenterology; Cancer; Combination therapy; Oncology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007464461,0.001219654,0.001941283,0.0003900409,0.0003988472,0.0006655469,0.0005403712,0.0006238043,0.001428987],"category_scores_gemma":[0.0004062928,0.0005801923,0.0007415822,0.0003883101,0.0008756772,0.0004703428,0.0002921163,0.002180855,0.0004388636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006933659,"about_ca_system_score_gemma":0.001237432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009252033,"about_ca_topic_score_gemma":0.002382902,"domain_scores_codex":[0.9997768,0.00009070979,0.00001305372,0.00003883165,0.00002550282,0.00005510843],"domain_scores_gemma":[0.9996741,0.00003810446,0.00004322501,0.00003272873,0.00001960632,0.0001921307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4945945,0.1202606,0.01341618,0.00163807,0.001442662,0.000816944,0.0007279929,0.005989201,0.1956995,0.0006667328,0.003919069,0.1608286],"study_design_scores_gemma":[0.2742823,0.6854225,0.01707887,0.0000513109,0.0005038619,0.0008668812,0.0001102524,0.001948479,0.0146712,0.0001923413,0.004820236,0.00005171028],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948691,0.001662927,0.0004899229,0.0002163104,0.0001137592,0.00106216,0.000306204,0.00005865765,0.001220933],"genre_scores_gemma":[0.9928402,0.001929567,0.001455984,0.000358436,0.00009761516,0.0009784217,0.0009190482,0.00001314002,0.00140757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001941283,"threshold_uncertainty_score":0.005030751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07047800656013627,"score_gpt":0.4378699529383543,"score_spread":0.3673919463782181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}