{"id":"W3046484172","doi":"10.1016/j.nicl.2020.102367","title":"White matter hyperintensities and neuropsychiatric symptoms in mild cognitive impairment and Alzheimer’s disease","year":2020,"lang":"en","type":"article","venue":"NeuroImage Clinical","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; Montreal Neurological Institute and Hospital; University of Toronto; Discovery Centre","funders":"Johnson and Johnson Pharmaceutical Research and Development; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; H. Lundbeck A/S; Servier; Fujirebio Europe; Eisai; Elan; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Eli Lilly and Company; U.S. Department of Defense; Johnson and Johnson; Meso Scale Diagnostics; Takeda Pharmaceutical Company; Janssen Alzheimer Immunotherapy Research And Development; AbbVie; Merck; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Foundation for the National Institutes of Health","keywords":"Hyperintensity; Cognitive impairment; White matter; Disease; Psychology; Cognition; Alzheimer's disease; Neuroscience; Medicine; Cognitive reserve; Magnetic resonance imaging; Audiology; Internal medicine; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008743523,0.000339944,0.0003463796,0.001090441,0.0007421156,0.0005642739,0.0003312701,0.0004511216,0.0008236377],"category_scores_gemma":[0.002345524,0.0003973566,0.0003396143,0.0006064288,0.0003602095,0.000419869,0.0005694168,0.0003983801,0.0001435288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003911339,"about_ca_system_score_gemma":0.000254615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009891893,"about_ca_topic_score_gemma":0.01348419,"domain_scores_codex":[0.9997105,0.00008592789,0.00003821068,0.00006983344,0.00005853389,0.00003698547],"domain_scores_gemma":[0.9992256,0.0001158801,0.0003516106,0.00006507344,0.00005867441,0.000183011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002639138,0.00006600406,0.9975446,0.000009262826,0.00008515947,0.0001258647,0.0001097366,0.00003780338,0.0002832538,0.00001407699,0.00003933408,0.001420961],"study_design_scores_gemma":[0.000003561559,0.00006088148,0.9996183,0.000001647084,0.00001241749,0.0001537086,0.00003762612,0.00003837785,0.00002438337,0.00001898604,0.00002886176,0.000001188437],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995542,0.0001946285,0.00002093226,0.00001450595,0.00000286103,0.000004329514,0.00005194017,0.000001265441,0.0001552936],"genre_scores_gemma":[0.9996246,0.0000707726,0.00004489173,0.0000134299,0.00000729514,0.000004397152,0.0001148833,6.029768e-7,0.0001190553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009891893,"threshold_uncertainty_score":0.01966864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05810830374780773,"score_gpt":0.3641789455570376,"score_spread":0.3060706418092298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}