{"id":"W3046484172","doi":"10.1016/j.nicl.2020.102367","title":"White matter hyperintensities and neuropsychiatric symptoms in mild cognitive impairment and Alzheimer’s disease","year":2020,"lang":"en","type":"article","venue":"NeuroImage Clinical","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; Montreal Neurological Institute and Hospital; University of Toronto; Discovery Centre","funders":"Johnson and Johnson Pharmaceutical Research and Development; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; H. Lundbeck A/S; Servier; Fujirebio Europe; Eisai; Elan; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Eli Lilly and Company; U.S. Department of Defense; Johnson and Johnson; Meso Scale Diagnostics; Takeda Pharmaceutical Company; Janssen Alzheimer Immunotherapy Research And Development; AbbVie; Merck; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Foundation for the National Institutes of Health","keywords":"Hyperintensity; Cognitive impairment; White matter; Disease; Psychology; Cognition; Alzheimer's disease; Neuroscience; Medicine; Cognitive reserve; Magnetic resonance imaging; Audiology; Internal medicine; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002456193,0.0002091599,0.0003904087,0.0001108329,0.00005259783,0.00006322374,0.00006078295,0.00005404834,0.0002787138],"category_scores_gemma":[0.0002785714,0.0001821771,0.000106705,0.0001977486,0.000378112,0.000112716,0.0002346586,0.0005236006,0.0001264598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005301647,"about_ca_system_score_gemma":0.00007129109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005373843,"about_ca_topic_score_gemma":0.000001198844,"domain_scores_codex":[0.9979237,0.0002598144,0.0004764725,0.0006964352,0.0002922465,0.000351335],"domain_scores_gemma":[0.998664,0.0002746309,0.00005798306,0.0001508208,0.0001058723,0.0007467319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002166279,0.000361068,0.9918801,0.00008345856,0.00004835332,0.0008996262,0.0001137731,6.994052e-8,0.00002039995,0.000003737205,0.001560633,0.002862527],"study_design_scores_gemma":[0.004745791,0.001848373,0.9917335,0.00007570285,0.0003095311,0.00005555306,0.0001908802,0.0005697978,0.000009545538,0.00001732778,0.0002890344,0.0001549853],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977322,0.0006379275,0.00001548734,0.0200271,0.0001044408,0.0007731688,0.00002584221,0.0000426432,0.001051375],"genre_scores_gemma":[0.9703186,0.0005557867,0.00005827842,0.02862367,0.0001976855,0.00003033329,0.00001468205,0.00003335965,0.0001676377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008596566,"threshold_uncertainty_score":0.7428965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05810830374780773,"score_gpt":0.3641789455570376,"score_spread":0.3060706418092298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}