{"id":"W3046539828","doi":"10.1016/j.jmoldx.2020.06.002","title":"Poly (ADP Ribose) Polymerase Inhibitors for Cancer","year":2020,"lang":"en","type":"article","venue":"Journal of Molecular Diagnostics","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network","funders":"Loxo Oncology; EMD Serono; Association for Molecular Pathology; Janssen Pharmaceuticals; AstraZeneca; Merck; Astellas Pharma; Astellas Pharma US; Pfizer; Bristol-Myers Squibb","keywords":"Poly ADP ribose polymerase; Polymerase; Carcinogenesis; PARP inhibitor; Ovarian cancer; Cancer research; Homologous recombination; Cancer; Germline; Breast cancer; Biology; Genetics; Medicine; Gene; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003910763,0.0002941581,0.0002716589,0.000424342,0.0002371905,0.000740609,0.000242608,0.0005095753,0.005975388],"category_scores_gemma":[0.0003681782,0.00010459,0.0002387551,0.0003963344,0.0002790073,0.0003781595,0.0002938846,0.001572394,0.002026464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004430309,"about_ca_system_score_gemma":0.0004719596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003072998,"about_ca_topic_score_gemma":0.001210971,"domain_scores_codex":[0.9998895,0.00002287594,0.000007660719,0.00001459858,0.00004540102,0.0000199412],"domain_scores_gemma":[0.9998558,0.00004002694,0.0000362342,0.000009178108,0.00002899695,0.00002977172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008230101,0.0003451445,0.0007059764,0.001086785,0.00006774229,0.0004905706,0.00005351308,0.0007781205,0.03438483,0.01461758,0.05472242,0.8919244],"study_design_scores_gemma":[0.0003021316,0.001525414,0.002866806,0.0004927426,0.00009040855,0.003101504,0.00005592476,0.0009789928,0.03085957,0.008791555,0.950908,0.00002697784],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.01740894,0.9154232,0.00595814,0.01850534,0.003049843,0.00007558757,0.0003766544,0.0002873002,0.03891504],"genre_scores_gemma":[0.2000691,0.7404765,0.007265276,0.006223175,0.002158508,0.00009013449,0.0006118924,0.0000437398,0.04306169],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005975388,"threshold_uncertainty_score":0.01998967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02667194500383148,"score_gpt":0.3240744884974056,"score_spread":0.2974025434935741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}