{"id":"W3046594723","doi":"10.1038/s41467-020-17680-w","title":"European polygenic risk score for prediction of breast cancer shows similar performance in Asian women","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Global Cancer Incidence and Screening","field":"Medicine","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Queen's University; University of British Columbia","funders":"Medical Research Council; Canadian Institutes of Health Research; Universiti Malaya; National Cancer Institute; Biomedical Research Council; National Medical Research Council; National Research Foundation; European Commission; Wellcome Trust; Yayasan Sime Darby; National Research Foundation Singapore; Fondation du cancer du sein du Québec; National Institutes of Health; Cancer Research UK; Government of Canada; Genome Canada","keywords":"Breast cancer; Medicine; Polygenic risk score; Malay; Prospective cohort study; Cohort; Oncology; Demography; Risk assessment; Cancer; Cohort study; Internal medicine; Gynecology; Biology; Gene; Genetics; Genotype; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005901183,0.0006068939,0.0004911616,0.001407533,0.0003465366,0.0009765308,0.0003391099,0.0004786521,0.001477293],"category_scores_gemma":[0.009944847,0.0001603995,0.001455778,0.001217441,0.000341899,0.0004677332,0.0007425542,0.0004088556,0.0004988801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000211613,"about_ca_system_score_gemma":0.0003077548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005436792,"about_ca_topic_score_gemma":0.005541279,"domain_scores_codex":[0.997941,0.001161678,0.00018167,0.0003136684,0.0002473812,0.0001547232],"domain_scores_gemma":[0.9958531,0.001795003,0.0008102263,0.0006316073,0.0005861345,0.0003240088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003598398,0.00002200565,0.9859976,0.00002194232,0.0006221632,0.0000790741,0.00007345781,0.0007768209,0.0004794514,0.00009193206,0.0003486628,0.0111271],"study_design_scores_gemma":[0.00002343893,0.0002186857,0.9925346,0.00001848416,0.0003053378,0.0003808004,0.00011885,0.004864373,0.0004308638,0.0002959593,0.0007909776,0.00001765543],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925844,0.0007654403,0.002506605,0.0002096117,0.00003596356,0.00002146651,0.0009213033,0.0000656669,0.002889479],"genre_scores_gemma":[0.9976387,0.0001443869,0.001070764,0.00003911457,0.00001591641,0.000009465284,0.0007479424,0.00001231009,0.0003213238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005901183,"threshold_uncertainty_score":0.03120881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06908215395686262,"score_gpt":0.3283954876487046,"score_spread":0.259313333691842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}