{"id":"W3046594723","doi":"10.1038/s41467-020-17680-w","title":"European polygenic risk score for prediction of breast cancer shows similar performance in Asian women","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Global Cancer Incidence and Screening","field":"Medicine","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Queen's University; University of British Columbia","funders":"Medical Research Council; Canadian Institutes of Health Research; Universiti Malaya; National Cancer Institute; Biomedical Research Council; National Medical Research Council; National Research Foundation; European Commission; Wellcome Trust; Yayasan Sime Darby; National Research Foundation Singapore; Fondation du cancer du sein du Québec; National Institutes of Health; Cancer Research UK; Government of Canada; Genome Canada","keywords":"Breast cancer; Medicine; Polygenic risk score; Malay; Prospective cohort study; Cohort; Oncology; Demography; Risk assessment; Cancer; Cohort study; Internal medicine; Gynecology; Biology; Gene; Genetics; Genotype; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002692165,0.00009190951,0.0001830283,0.00006204082,0.0001096085,0.000007394544,0.0004281213,0.0001014571,0.00003703765],"category_scores_gemma":[0.0001376475,0.00008602227,0.00006054972,0.0003802954,0.00007075375,0.0001145415,0.0001169801,0.0006864399,0.000003094104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001390919,"about_ca_system_score_gemma":0.0001212984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004139077,"about_ca_topic_score_gemma":0.0002985391,"domain_scores_codex":[0.9991907,0.00007743189,0.0002560092,0.0001506256,0.000154985,0.0001702528],"domain_scores_gemma":[0.9989291,0.00004188316,0.0001245694,0.0006259995,0.0001699844,0.0001084883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004078711,0.00008079561,0.9700189,0.0001086035,0.00006788889,0.000001041397,0.00274533,0.0001117153,0.001859054,0.0002007397,0.00267652,0.02172157],"study_design_scores_gemma":[0.000897134,0.0001719689,0.9784857,0.0001913527,0.00006041824,0.000008252972,0.0006240455,0.003870318,0.0001515995,0.00001323835,0.01545531,0.00007068693],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.960424,0.00672408,0.000129269,0.02296882,0.00009938265,0.0008106758,0.001577098,0.00008563004,0.007181029],"genre_scores_gemma":[0.9951738,0.001667506,0.001477725,0.001340489,0.0001168865,0.00007807556,0.0001007396,0.00001693561,0.0000278239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0347498,"threshold_uncertainty_score":0.3507886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06908215395686262,"score_gpt":0.3283954876487046,"score_spread":0.259313333691842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}