{"id":"W3046623468","doi":"10.3389/fbioe.2020.00891","title":"Bovine Milk Extracellular Vesicles Are Osteoprotective by Increasing Osteocyte Numbers and Targeting RANKL/OPG System in Experimental Models of Bone Loss","year":2020,"lang":"en","type":"article","venue":"Frontiers in Bioengineering and Biotechnology","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Universidade Federal de Minas Gerais; Fundação de Amparo à Pesquisa do Estado de Minas Gerais; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Universidade de São Paulo; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Arthritis Society; Dutch Arthritis Society","keywords":"Osteocyte; RANKL; Osteoclast; Endocrinology; Internal medicine; Osteoprotegerin; Chemistry; Bone mineral; Bone remodeling; Bone resorption; Extracellular vesicle; Medicine; Osteoblast; Microvesicles; Osteoporosis; Receptor; Biochemistry; microRNA; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000233713,0.0002568002,0.0004106497,0.0001620322,0.00003843197,0.00001363199,0.0001525786,0.0004409785,5.392292e-7],"category_scores_gemma":[0.00009083786,0.0002864288,0.00004761032,0.0002282998,0.0002645141,0.00001586061,0.0002078263,0.0002510868,2.028933e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000505618,"about_ca_system_score_gemma":0.00001670554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006929998,"about_ca_topic_score_gemma":0.000003696393,"domain_scores_codex":[0.9985622,0.00006913863,0.0004006626,0.0005380354,0.00009795556,0.0003320265],"domain_scores_gemma":[0.9995325,0.000009286005,0.0001358642,0.0001970924,0.0000186813,0.0001065545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003847296,0.00004633796,0.005100646,0.0002741361,0.00003528976,0.00007048062,0.0002168671,0.0005317806,0.9922203,0.00006118142,0.00009768334,0.0009605724],"study_design_scores_gemma":[0.001419994,0.0002562887,0.0001589658,0.0001553917,0.00001525066,0.00004536759,0.004108682,0.02481035,0.9684083,0.00002646526,0.0002699672,0.0003249583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9113255,0.0699754,0.01798631,0.0002370432,0.00008188698,0.0002944835,0.00003446886,0.00005496617,0.000009984838],"genre_scores_gemma":[0.9882192,0.0004967367,0.01113428,0.00002023079,0.00003479571,0.0000238239,0.00002853572,0.00003760777,0.000004809083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07689372,"threshold_uncertainty_score":0.9999588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004685294262275631,"score_gpt":0.1861885120644928,"score_spread":0.1815032178022171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}