{"id":"W3046696379","doi":"10.2174/1573408016999200729110245","title":"Insight into the Mechanism of 17β-Hydroxysteroid Dehydrogenase Type 3 Inhibition by the Androsterone Derivative RM-532-105","year":2020,"lang":"en","type":"article","venue":"Current Enzyme Inhibition","topic":"Hormonal and reproductive studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec","funders":"","keywords":"Chemistry; Cofactor; Hydroxysteroid dehydrogenase; Mechanism of action; Enzyme; Androsterone; Docking (animal); Dehydrogenase; Stereochemistry; Active site; Biotinylation; Non-competitive inhibition; Binding site; Biochemistry; Steroid; In vitro; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001365686,0.0006474933,0.0003838995,0.0001665373,0.0001414942,0.0004568532,0.0006336576,0.0003228884,0.005160291],"category_scores_gemma":[0.000098624,0.0001746281,0.000590476,0.0001336267,0.000228584,0.0003469943,0.00016051,0.0006045005,0.001512642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003962005,"about_ca_system_score_gemma":0.0004281172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001138131,"about_ca_topic_score_gemma":0.0009021002,"domain_scores_codex":[0.9999334,0.00001148567,0.00000349261,0.00001136988,0.00001902057,0.00002122935],"domain_scores_gemma":[0.9999664,0.0000091913,0.000008767363,0.000003518407,0.00000612408,0.000005996965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001303649,0.0006700363,0.002281175,0.001812958,0.0001590845,0.00163254,0.0001131132,0.01356786,0.9247772,0.01105731,0.002798688,0.03982637],"study_design_scores_gemma":[0.0005522518,0.003704259,0.007029111,0.000192981,0.0004568175,0.004547576,0.0002202996,0.06072179,0.8767711,0.004407058,0.04128116,0.0001155325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8363133,0.06205247,0.0579547,0.002893823,0.0003441647,0.0002981171,0.001934678,0.0009942813,0.03721447],"genre_scores_gemma":[0.9737064,0.01450549,0.005978803,0.0003662916,0.00002537275,0.00004827123,0.0008754606,0.00002856514,0.004465379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005160291,"threshold_uncertainty_score":0.01726294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03390412300118913,"score_gpt":0.2724590194099311,"score_spread":0.238554896408742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}