{"id":"W3046696379","doi":"10.2174/1573408016999200729110245","title":"Insight into the Mechanism of 17β-Hydroxysteroid Dehydrogenase Type 3 Inhibition by the Androsterone Derivative RM-532-105","year":2020,"lang":"en","type":"article","venue":"Current Enzyme Inhibition","topic":"Hormonal and reproductive studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec","funders":"","keywords":"Chemistry; Cofactor; Hydroxysteroid dehydrogenase; Mechanism of action; Enzyme; Androsterone; Docking (animal); Dehydrogenase; Stereochemistry; Active site; Biotinylation; Non-competitive inhibition; Binding site; Biochemistry; Steroid; In vitro; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002424419,0.0002422354,0.0003431461,0.00004902495,0.0002637021,0.00001910743,0.00007515209,0.00007100844,0.00004474237],"category_scores_gemma":[0.0002043027,0.0001309468,0.0001173575,0.0004667297,0.0003206112,0.0001509459,0.0001443134,0.0003544685,0.00006682495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007767448,"about_ca_system_score_gemma":0.00005627169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002068286,"about_ca_topic_score_gemma":0.000008201441,"domain_scores_codex":[0.998353,0.0001586895,0.0004253324,0.0004106916,0.0004346704,0.0002176387],"domain_scores_gemma":[0.999032,0.0000674898,0.0002204878,0.0002692795,0.000305505,0.0001052753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003883685,0.0003103203,0.0001374319,0.0002837573,0.0001312241,0.00001082165,0.0209221,0.000006520233,0.9621533,0.002007762,0.009766798,0.003881587],"study_design_scores_gemma":[0.001149758,0.0007990103,0.000320823,0.0002933477,0.0001425948,0.00002505707,0.001273199,0.0001618269,0.9842829,0.001256024,0.01011506,0.0001803927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9752308,0.00923609,0.001319614,0.01229418,0.0003459432,0.0009125706,0.00004172034,0.00006371081,0.0005553996],"genre_scores_gemma":[0.9979048,0.0004808595,0.00002606046,0.0007398212,0.0005101956,0.0000600938,0.0002008498,0.00002441307,0.00005294525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02267398,"threshold_uncertainty_score":0.5339855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03390412300118913,"score_gpt":0.2724590194099311,"score_spread":0.238554896408742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}