{"id":"W3046703180","doi":"10.1021/acschemneuro.0c00410","title":"Contingency between Historical Substitutions in the Acetylcholine Receptor Pore","year":2020,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Conductance; Protein subunit; Acetylcholine receptor; Biology; Acetylcholine; Residue (chemistry); Wild type; Phylogenetics; Receptor; Biophysics; Genetics; Biochemistry; Gene; Endocrinology; Physics; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004500935,0.0001656026,0.0002030689,0.0004756028,0.0003256196,0.0004196359,0.000193443,0.0003888942,0.001131654],"category_scores_gemma":[0.0008023118,0.0001446803,0.0001910431,0.0003860025,0.0004933,0.0004491936,0.0003811204,0.000364185,0.0002199536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002402657,"about_ca_system_score_gemma":0.0001438165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003605266,"about_ca_topic_score_gemma":0.001094039,"domain_scores_codex":[0.9997464,0.00006287893,0.00002226361,0.00009897436,0.0000377507,0.00003166637],"domain_scores_gemma":[0.9995961,0.0001252417,0.0001335417,0.00004939033,0.00004977286,0.00004588886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008300271,0.00006695894,0.1600122,0.0001476256,0.0002424675,0.001981013,0.0009945584,0.00365291,0.8003314,0.004521811,0.0001369926,0.02708207],"study_design_scores_gemma":[0.00003707253,0.000620761,0.8931248,0.00006182093,0.0004052526,0.008015582,0.0009808077,0.01060007,0.07227014,0.003638774,0.01014222,0.0001028576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969516,0.0002937559,0.001734054,0.00003611972,0.00000784154,0.000003806163,0.00004785186,0.00001477204,0.0009101852],"genre_scores_gemma":[0.9988715,0.0001974318,0.0006683586,0.00002138508,0.000007075702,0.000002008872,0.00005709598,0.00001024827,0.0001648774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001131654,"threshold_uncertainty_score":0.003785729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04090931789093921,"score_gpt":0.2778119914061314,"score_spread":0.2369026735151922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}