{"id":"W3046834349","doi":"10.3390/molecules25153540","title":"New Series of Double-Modified Colchicine Derivatives: Synthesis, Cytotoxic Effect and Molecular Docking","year":2020,"lang":"en","type":"article","venue":"Molecules","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Cytotoxicity; Colchicine; Chemistry; Docking (animal); Cisplatin; Tubulin; Stereochemistry; Doxorubicin; In vitro; Cytotoxic T cell; Cell culture; Biochemistry; Microtubule; Biology; Cell biology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003362548,0.0003930241,0.0003002171,0.0001902248,0.0001087683,0.0001496368,0.0002371217,0.000167048,0.002445925],"category_scores_gemma":[0.00007016455,0.00007961134,0.0001666561,0.0002421964,0.0001043921,0.0001610129,0.000111741,0.0003765803,0.0004877034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002470627,"about_ca_system_score_gemma":0.0001526791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009641599,"about_ca_topic_score_gemma":0.002076121,"domain_scores_codex":[0.9999738,0.000003799961,0.000001800059,0.000006672281,0.000006512989,0.000007400659],"domain_scores_gemma":[0.9999733,0.000003052875,0.000007186127,0.000001959464,0.000005596177,0.000008894517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004651938,0.000121822,0.000324157,0.000762691,0.00005034702,0.0004637731,0.00003931724,0.002337748,0.9669096,0.0005738074,0.001135358,0.0268162],"study_design_scores_gemma":[0.0001653032,0.003126738,0.003441067,0.0000418924,0.000117174,0.0009235861,0.00004221694,0.003760583,0.9416466,0.0001468116,0.04653847,0.00004949485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.932855,0.027322,0.0147171,0.0004453641,0.0003924852,0.0003729516,0.002576018,0.0005088974,0.02081026],"genre_scores_gemma":[0.9614872,0.01087044,0.01808563,0.0001585808,0.0000432949,0.0001318096,0.001528251,0.00006169058,0.007633006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002445925,"threshold_uncertainty_score":0.008182466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02067006973477521,"score_gpt":0.2407110168522142,"score_spread":0.220040947117439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}