{"id":"W3046834349","doi":"10.3390/molecules25153540","title":"New Series of Double-Modified Colchicine Derivatives: Synthesis, Cytotoxic Effect and Molecular Docking","year":2020,"lang":"en","type":"article","venue":"Molecules","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Cytotoxicity; Colchicine; Chemistry; Docking (animal); Cisplatin; Tubulin; Stereochemistry; Doxorubicin; In vitro; Cytotoxic T cell; Cell culture; Biochemistry; Microtubule; Biology; Cell biology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007737617,0.0002056848,0.0004101146,0.00001875998,0.00005106573,0.00002869321,0.0001574662,0.0001169781,0.0001537731],"category_scores_gemma":[0.0003457453,0.0001501501,0.00008955988,0.0001073654,0.00009954375,0.00005717368,0.0001162897,0.0001154796,0.000002954486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001046271,"about_ca_system_score_gemma":0.00001936567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004344644,"about_ca_topic_score_gemma":0.000002200436,"domain_scores_codex":[0.999087,0.00005300233,0.0002014699,0.0003248434,0.0001488841,0.0001847444],"domain_scores_gemma":[0.9992839,0.000288412,0.0001123888,0.0001588516,0.00002230206,0.0001342107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004654366,0.0000247747,0.001593165,0.000217033,0.00006901292,0.00002167317,0.00008273836,0.00002188587,0.9882872,0.0008718193,0.00002792118,0.008317315],"study_design_scores_gemma":[0.0004984307,0.0001303481,0.0009732612,0.00009621179,0.0000450757,0.000006012589,0.00005339327,0.0001124851,0.9973963,0.000139952,0.0003741282,0.0001743836],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922978,0.0004865213,0.00109415,0.0008744573,0.000008552066,0.00009923478,0.00001322599,0.00006958337,0.005056516],"genre_scores_gemma":[0.9990244,0.00004223559,0.0006913733,0.0001354287,0.00005183034,0.00001836505,0.000004068359,0.00001637683,0.00001592171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009109092,"threshold_uncertainty_score":0.6122942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02067006973477521,"score_gpt":0.2407110168522142,"score_spread":0.220040947117439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}