{"id":"W3046861920","doi":"10.1016/j.isci.2020.101433","title":"Interleukin-10 and Small Molecule SHIP1 Allosteric Regulators Trigger Anti-inflammatory Effects through SHIP1/STAT3 Complexes","year":2020,"lang":"en","type":"article","venue":"iScience","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of Manitoba; Vancouver Coastal Health Research Institute; University of British Columbia; Vancouver Coastal Health","funders":"National Research Council Canada; Western Economic Diversification Canada; Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Canadian Cancer Society; Michael Smith Health Research BC; University of Saskatchewan","keywords":"Allosteric regulation; STAT3; Chemistry; Interleukin 10; Cell biology; Receptor; Signal transduction; Biology; Biochemistry; Cytokine; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005367856,0.0003241579,0.0002530393,0.0001032044,0.000221831,0.0001581564,0.0002816299,0.0003513413,0.01684861],"category_scores_gemma":[0.00006928748,0.0001038455,0.000373333,0.0001604044,0.0001616999,0.0001838808,0.0001458651,0.0007354691,0.00153079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003977259,"about_ca_system_score_gemma":0.0002375558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009513013,"about_ca_topic_score_gemma":0.001617631,"domain_scores_codex":[0.9999511,0.000003922979,0.000001401468,0.000007044648,0.00001900289,0.00001754051],"domain_scores_gemma":[0.9999801,0.000004551267,0.000004008328,0.00000133017,0.000002217133,0.000007722379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001737964,0.0001503228,0.0003167803,0.0006629116,0.00004486656,0.0005584828,0.00003937293,0.001474013,0.9596177,0.001686241,0.01661148,0.01709988],"study_design_scores_gemma":[0.0004500506,0.0006790935,0.005774374,0.00003753518,0.00004265687,0.0005678727,0.00006685865,0.01170718,0.9258482,0.0005225913,0.05427649,0.00002715089],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8572326,0.02234443,0.02589304,0.005564378,0.002877552,0.0003825627,0.01712926,0.002718068,0.06585801],"genre_scores_gemma":[0.9348031,0.01180223,0.01286438,0.0007348911,0.0001839091,0.00026074,0.006166744,0.0001151648,0.03306885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01684861,"threshold_uncertainty_score":0.05636424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02001067256276893,"score_gpt":0.2546927415076766,"score_spread":0.2346820689449076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}