{"id":"W3046884054","doi":"10.1101/2020.08.02.233536","title":"Cross-neutralization of a SARS-CoV-2 antibody to a functionally conserved site is mediated by avidity","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Infection and Immunity; Basic Energy Sciences; National Institute of General Medical Sciences; Office of Science; National Institutes of Health; SLAC National Accelerator Laboratory; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Biological and Environmental Research; Bill and Melinda Gates Foundation; U.S. Department of Energy","keywords":"Avidity; Epitope; Neutralization; Antibody; Glycoprotein; Virology; Cross-reactivity; Epitope mapping; Chemistry; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Binding site; Biology; Coronavirus disease 2019 (COVID-19); Biochemistry; Immunology; Medicine; Cross reactions","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007836684,0.0006993809,0.001183209,0.0005010659,0.0001387651,0.0002075064,0.0005776277,0.0008238064,0.00005193062],"category_scores_gemma":[0.001329588,0.0007474659,0.0003454369,0.001574782,0.0002736463,0.0001647521,0.0006404505,0.00104817,0.0003575932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003795981,"about_ca_system_score_gemma":0.002280178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005889371,"about_ca_topic_score_gemma":0.00001250273,"domain_scores_codex":[0.9952643,0.0001946665,0.001043856,0.001524365,0.001260545,0.0007122969],"domain_scores_gemma":[0.995582,0.0001700912,0.0005108747,0.001412172,0.002082702,0.0002422053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006251399,0.0003186133,0.1610508,0.001219952,0.0003272125,0.00008849632,0.00003517096,0.000001517918,0.8312947,0.00004854347,0.004989293,5.103722e-7],"study_design_scores_gemma":[0.001545765,0.0002370377,0.1293539,0.0004692684,0.0001706264,5.885673e-8,0.000001513692,0.0004673691,0.8146472,0.000001592771,0.05257128,0.0005343943],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909963,0.0005728168,0.002336505,0.00153616,0.0005566091,0.001729538,0.001811953,0.0004333903,0.00002674046],"genre_scores_gemma":[0.9586619,0.00003780879,0.0006999022,0.03985787,0.0003528192,0.0001982729,0.00001068801,0.0001765276,0.000004199888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04758199,"threshold_uncertainty_score":0.9994977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05083113356770191,"score_gpt":0.3364121962823283,"score_spread":0.2855810627146264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}