{"id":"W3046884054","doi":"10.1101/2020.08.02.233536","title":"Cross-neutralization of a SARS-CoV-2 antibody to a functionally conserved site is mediated by avidity","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Infection and Immunity; Basic Energy Sciences; National Institute of General Medical Sciences; Office of Science; National Institutes of Health; SLAC National Accelerator Laboratory; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Biological and Environmental Research; Bill and Melinda Gates Foundation; U.S. Department of Energy","keywords":"Avidity; Epitope; Neutralization; Antibody; Glycoprotein; Virology; Cross-reactivity; Epitope mapping; Chemistry; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Binding site; Biology; Coronavirus disease 2019 (COVID-19); Biochemistry; Immunology; Medicine; Cross reactions","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002252588,0.0003625336,0.0002372488,0.0001191326,0.0001500271,0.0002888531,0.000336971,0.0003221673,0.003058275],"category_scores_gemma":[0.0001749522,0.0001521332,0.0002850678,0.0001043815,0.0002230301,0.0002047272,0.0003148024,0.0005246664,0.0006045146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003659286,"about_ca_system_score_gemma":0.0001869101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008549503,"about_ca_topic_score_gemma":0.0007492361,"domain_scores_codex":[0.999877,0.00001920959,0.000005533681,0.00002791884,0.00003699703,0.00003347772],"domain_scores_gemma":[0.9999539,0.000009191764,0.00001086897,0.000007972611,0.000008644206,0.00000947199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008175978,0.00002810937,0.001371909,0.00003425414,0.00001542226,0.0001358631,0.00002889532,0.000333257,0.9947372,0.0005261365,0.0001584742,0.002548758],"study_design_scores_gemma":[0.00004955719,0.0001640077,0.009609932,0.000009974771,0.00001432034,0.0008893746,0.00003327027,0.004273909,0.9777093,0.0002983874,0.006941753,0.000006106714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872328,0.0007379656,0.007054263,0.0001413331,0.00002553949,0.00001829046,0.0001659127,0.00007925642,0.004544706],"genre_scores_gemma":[0.9940941,0.0002135741,0.003062784,0.0001028025,0.000004876958,0.000008027338,0.0003917622,0.00002282893,0.002099282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003058275,"threshold_uncertainty_score":0.01023096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05083113356770191,"score_gpt":0.3364121962823283,"score_spread":0.2855810627146264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}